White, Ian Richard2021-09-132021-09-131998Sarıcaoğlu, H. vd. (1998). "Prevention of nickel-induced allergic contact reactions with pentoxifylline". Contact Dermatitis, 39(5), 244-247.0105-1873https://doi.org/10.1111/j.1600-0536.1998.tb05917.xhttps://onlinelibrary.wiley.com/doi/10.1111/j.1600-0536.1998.tb05917.xhttp://hdl.handle.net/11452/21880In this study, we investigated the effect of pentoxifylline, an inhibitor of TNF-alpha, on the contact sensitivity response induced by nickel. For induction, open epicutaneous sensitization by NiSO4 . 6 H2O (25% aq.) solution was applied on the backs of 38 albino guinea pigs 5 days a week for 4 weeks. NaCl (0.9%) solution was applied epicutaneously to 10 albino-guinea pigs as a control group. 19 were sensitized by nickel and developed positive patch test reactions. Patch tests were repeated after 10 of the sensitized pigs were given pentoxifylline 20 mg/kg/day orally. At the end of this study, only 2 positive patch test reactions were observed in the pentoxifylline-treated group, while 7/9 of the untreated guinea pigs developed positive reactions. These results suggest that pentoxifylline inhibits the contact sensitivity response induced by nickel only during drug administration.eninfo:eu-repo/semantics/closedAccessAllergyDermatologyPentoxifyllineExperimental nickel sensitizationGuinea pigsInhibition elicitation phaseGuinea-pigHypersensitivity reactionsElicitation phaseDermatitisSensitizationVasculitisIrritantDiseaseArticle0000772707000062-s2.0-00317571622442473959840261AllergyDermatologyLocal Lymph Node Assay; Skin Allergy; SensitizationAntithrombocytic agentNickelNickel sulfatePentoxifyllineTumor necrosis factor alphaAnimal experimentAnimal modelContact dermatitisContact sensitivityControlled studyGuinea pigNonhumanOral drug administrationPatch test