2022-12-062022-12-062020-06-28De Sanctis, V. vd. (2020). "Preliminary data on COVID-19 in patients with hemoglobinopathies: A multicentre ICET-A study". Mediterranean Journal of Hematology and Infectious Diseases, 12.2035-3006https://doi.org/10.4084/MJHID.2020.046https://www.mjhid.org/index.php/mjhid/article/view/2020.046http://hdl.handle.net/11452/29712Bu çalışmada 31 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır.Objectives: This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory results, radiologic findings, and outcomes of COVID-19 in patients with transfusion-dependent beta thalassemia major (TM), beta-thalassemia intermedia (TI) and sickle cell disease (SCD). Design: A total of 17 Centers, from 10 countries, following 9,499 patients with hemoglobinopathies, participated in the survey. Main outcome data: Clinical, laboratory, and radiologic findings and outcomes of patients with COVID-19 were collected from medical records and summarized. Results: A total of 13 patients, 7 with TM, 3 with TI, and 3 with SCD, with confirmed COVID-19, were identified in 6 Centers from different countries. The overall mean age of patients was 33.7 +/- 12.3 years (range:13-66); 9/13 (69.2%) patients were females. Six patients had pneumonia, and 4 needed oxygen therapy. Increased C-reactive protein (6/10), high serum lactate dehydrogenase (LDH; 6/10), and erythrocyte sedimentation rate (ESR; 6/10) were the most common laboratory findings. 6/10 patients had an exacerbation of anemia (2 with SCD). In the majority of patients, the course of COVID-19 was moderate (6/10) and severe in 3/10 patients. A 30-year-old female with TM, developed a critical SARS-CoV-2 infection, followed by death in an Intensive Care Unit. In one Center (Oman), the majority of suspected cases were observed in patients with SCD between the age of 21 and 40 years. A rapid clinical improvement of tachypnea/dyspnea and oxygen saturation was observed, after red blood cell exchange transfusion, in a young girl with SCD and worsening of anemia (Hb level from 9.2 g/dl to 6.1g/dl). Conclusions: The data presented in this survey permit an early assessment of the clinical characteristics of COVID 19 in different countries. 70% of symptomatic patients with COVID-19 required hospitalization. The presence of associated co-morbidities can aggravate the severity of COVID-19, leading to a poorer prognosis irrespective of age.eninfo:eu-repo/semantics/openAccessCOVID-19SARS-CoV-2Beta-thalassemiaSickle cell diseasePatients' characteristicsClinical courseRisk factorsBETAHematologyInfectious diseasesArticle0005466445000012-s2.0-85090438053232670524HematologyInfectious diseasesRadiological Findings; Clinical Features; COVID-19C reactive proteinLactate dehydrogenaseAdolescentAdultAgedAnemiaArticleCoronavirus disease 2019Disease courseDisease exacerbationDisease severityDyspneaErythrocyte sedimentation rateErythrocyte transfusionFemaleGeneral condition deteriorationGroups by ageHealth centerHealth surveyHemoglobinopathyHumanInformation processingIntensive care unitLactate dehydrogenase blood levelMajor clinical studyMale; medical recordOxygen saturationOxygen therapyPneumoniaProtein blood levelRetrospective studySevere acute respiratory syndrome coronavirus 2Sickle cell anemiaTachypneaThalassemia intermediaThalassemia majorTreatment outcome