2022-01-142022-01-142010-02Algın, O. vd. (2010). "The efficiency of PC-MRI in diagnosis of normal pressure hydrocephalus and prediction of shunt response". Academic Radiology, 17(2), 181-187.1076-63321878-4046https://doi.org/10.1016/j.acra.2009.08.011https://www.sciencedirect.com/science/article/abs/pii/S1076633209004966http://hdl.handle.net/11452/24098Rationale and Objectives: In this prospective study, we aimed to reveal the efficiency of phase-contrast magnetic resonance imaging (PC-MRI) in the diagnosis of idiopathic normal pressure hydrocephalus (INPH) and prediction of shunt response. Materials and Methods: The study group consisted of 43 patients with INPH diagnosis and 15 asymptomatic age-matched controls. PC-MRI studies were applied on cerebral aqueduct and superior sagittal sinus (SSS) in all the cases. Results: The maximum and mean cerebrospinal fluid (CSF) flow velocities were significantly higher in the INPH patients compared with the controls (P < .05). CSF stroke volume (43.2 +/- 63.8 mu L) and output/min (3921 +/- 5668 mu L) were remarkably higher in the NPH group compared with the control group (3.9 +/- 3.9 mu L, 439 +/- 487 mu L, respectively) (P < .05). Maximum and mean venous velocity values of the INPH patients (maximum, 19.2 +/- 4.3 cm/s; mean, 16 +/- 3.7 cm/s), were lower than those of the control group (maximum, 21.8 +/- 4.6 cm/s; mean, 18.9 +/- 3.9 cm/s) (P < .05). Stroke volume and venous output/min values of INPH patients in SSS, were significantly lower than those of the control group (P <.001, P = .007, respectively). The response of INPH patients against shunt treatment showed no statistical correlation with any of the PC-M RI parameters (P > .05). Conclusion: The measurement of CSF venous flow velocities with PC-MRI is a noninvasive test that benefits INPH diagnosis, but remains inadequate in prediction of response against shunt treatment.eninfo:eu-repo/semantics/closedAccessCerebral blood flowMagnetic resonance imagingNormal pressure hydrocephalusPC-MRICerebrospinal fluid flow dynamicsSubarachnoid spaceShuntCerebrospinal-fluid flowStroke volumeHealthy-volunteersCerebral aqueductArachnoid cystsPhaseDynamicsPathophysiologyQuantificationCommunicationRadiology, nuclear medicine & medical imagingAgedCerebrospinal fluidCerebrospinal fluid shuntsFemaleHumansHydrocephalus, normal pressureImage enhancementImage interpretation, computer-assistedMagnetic resonance imagingMaleMiddle agedPrognosisReproducibility of resultsSensitivity and specificityTreatment outcomeArticle0002738341000082-s2.0-7304911856818118717219910214Radiology, nuclear medicine & medical imagingNormal Pressure Hydrocephalus; Intracranial Pressure; Cerebrospinal Fluid ShuntingAdultAgedArticleBrain aqueductCerebrospinal fluid flowClinical articleControlled studyFemaleFlow rateHeart stroke volumeHumanMaleNormotensive hydrocephalusNuclear magnetic resonance imagingPhase contrast microscopyPredictionPriority journalProspective studyShuntingSuperior sagittal sinusTreatment response