New palladium(II) and platinum(ii) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2′-bipyridine and 2,2′-dipyridylamine: Synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity

Harrison, William T. A.Büyükgüngör, Orhan2022-06-092022-06-092015İçsel, C. vd. (2015). "New palladium(II) and platinum(ii) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2′-bipyridine and 2,2′-dipyridylamine: Synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity". Dalton Transactions, 44(15), 6880-6895.1477-9226https://doi.org/10.1039/c5dt00728chttps://pubs.rsc.org/en/content/articlelanding/2015/DT/C5DT00728Chttp://hdl.handle.net/11452/27003Novel palladium(II) and platinum(II) complexes of 5,5-diethylbarbiturate (barb) with 2-phenylpyridine (Hppy), 2,2'-bipyridine (bpy) and 2,2'-dipyridylamine (dpya) have been prepared and characterized by elemental analysis, IR, UV-Vis, NMR and ESI-MS. Single-crystal diffraction measurements show that complex 1 consists of binuclear [Pd-2(mu-barb-kappa N,O)(2)(ppy-kappa N,C)(2)] moieties, while complexes 3-5 are mononuclear, [M(barb-.kappa)(2)(L-kappa N,N')] (L = bpy or dpya). 6 has a composition of [Pt(dpya-kappa N,N')(2)][Ag(barb-kappa N)(2)](2)center dot 4H(2)O and 2 was assumed to have a structure of [Pt(barb-kappa N)(Hppy-kappa N)(ppy-kappa N,C)]center dot 3H(2)O. The complexes were found to exhibit significant DNA binding affinity by a non-covalent binding mode, in accordance with molecular docking studies. In addition, complexes 1 and 2 displayed strong binding with supercoiled pUC19 plasmid DNA. Cellular uptake studies were performed to assess the subcellular localization of the selected complexes. A moderate radical scavenging activity of 1 and 2 was confirmed by DPPH and ABTS tests. Complexes 1, 2, and 5 showed selectivity against HT-29 (colon) cell line.eninfo:eu-repo/semantics/openAccessLigand ruthenium(II) complexesRay crystal-structureMetal-complexesAntimicrobial activityThermal-propertiesModel nucleobasesMass-spectrometryAnticancer drugsMinor-grooveCancer-cellsChemistryBinding energyCell cultureComplexationDNAFree radicalsMobile securityMolecular modelingPlatinumSingle crystalsSynthesis (chemical)5 ,5-diethylbarbiturateAnti-oxidant activitiesDNA binding affinityMolecular dockingNoncovalent bindingRadical scavenging activitySingle-crystal diffractionSubcellular localizationsPalladium compounds2,2'-DipyridylAntioxidantsBarbituratesBenzothiazolesBiological transportBiphenyl compoundsCell line, tumorCell survivalCoordination complexesDNAHumansLigandsMolecular docking simulationPalladiumPicratesPlasmidsPlatinumPyridinesSulfonic acidsNew palladium(II) and platinum(ii) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2′-bipyridine and 2,2′-dipyridylamine: Synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicityArticle0003522719000222-s2.0-8492643353868806895441525771855Chemistry, inorganic & nuclearThiobarbituric Acid; Crystal Structure; DMV2,2' bipyridine2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid2,2'-dipyridylamine2,2-diphenyl-1-picrylhydrazyl2-phenylpyridineAntioxidantBarbituric acid derivativeBenzothiazole derivativeBiphenyl derivativeCoordination compoundDNALigandPalladiumPicric acidPlatinumPyridine derivativeSulfonic acid derivativeAnalogs and derivativesCell survivalChemistryDrug effectsHumanMolecular dockingPlasmidTransport at the cellular levelTumor cell line