2023-10-192023-10-192020-05Sağ, S. ve Gül, Ö. Ö. (2020). "Mental status and physical activity in patients with homozygous familial hypercholesterolemia: A subgroup analysis of a nationwide survey (A-HIT1 registry)". Journal of Clinical Lipidology, 14(3), 361-370.1933-28741876-4789https://doi.org/10.1016/j.jacl.2020.04.006https://www.sciencedirect.com/science/article/pii/S1933287420300763http://hdl.handle.net/11452/34465Bu çalışmada 23 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır.BACKGROUND: Homozygous familial hypercholesterolemia (HoFH) is a rare, life-threatening disease due to high serum low-density lipoprotein (LDL) cholesterol levels. LDL cholesterol-lowering interventions are fundamental for patients with HoFH. OBJECTIVE: It was aimed to investigate the association between the mental status of patients with HoFH and healthy lifestyle behaviors. METHODS: This subgroup analysis of the A-HIT1 population included the data of patients aged >= 18 years with a clinical diagnosis of HoFH undergoing therapeutic LDL apheresis. Besides the demographic and clinical characteristics of patients, healthy lifestyle behaviors were assessed, and psychiatric symptoms were screened by Symptom Check List (SCL-90-R). RESULTS: The highest percentage for pathology was observed in dimensions of obsessive-compulsive, somatization, interpersonal sensitivity, and depression in SCL-90-R. Patients with any cardiovascular condition have more psychiatric symptoms in different fields of SCL-90-R. The outcomes of the correlative analysis indicated that lower the age of the first coronary event better the psychiatric status, probably denoting a better adaptation to disease and its treatment. Among 68 patients, 36 patients were not exercising regularly. Patients with regular physical activity had significantly lower scores in most dimensions of SCL-90-R and there was no association between regular physical activity and other investigated variables. The strongest predictor of regular exercising was global severity index of SCL-90-R. CONCLUSION: In the HoFH population, there was a high prevalence of mental disturbances. Better psychiatric status was associated with regular exercising. Therefore, assessing the mental status of patients with HoFH and referring patients in need, to a psychiatrist, may improve the outcome of patients.eninfo:eu-repo/semantics/closedAccessPharmacology & pharmacyHomozygous familial hypercholesterolemiaGlobal severity indexHoFHLDLLDL apheresisMental statePhysical activityPsychiatryPsychopathologySymptom check listLDL-apheresisPatients perceptionsRisk-factorsSelfLifeInterventionDepressionManagementDisorderPeopleAdultAnticholesteremic agentsCholesterol, LDLExerciseFemaleHomozygoteHumansHyperlipoproteinemia type IIMaleMental healthMiddle agedPhenotypeRegistriesSurveys and questionnairesArticle0005405485000132-s2.0-8508509819236137014332423761Pharmacology & pharmacyFamilial hypercholesterolemia; Lomitapide; CholesterolSeverity of illness indexSex differenceSomatizationSymptom checklist 90BloodExerciseFamilial hypercholesterolemiaHomozygoteMental healthMiddle agedPathophysiologyPhenotypePsychologyQuestionnaireRegisterAtorvastatinEzetimibeLow density lipoproteinRosuvastatinHypocholesterolemic agentLow density lipoprotein cholesterolAdaptationAdultArticleClinical featureCross-sectional studyDemographyDepressionDisease severityFemaleGlobal severity indexHealthy lifestyleHomozygous familial hypercholesterolemiaHumanLipoprotein apheresisMajor clinical studyMaleMental diseaseObsessive compulsive disorderPhobiaPhysical activityPrevalencePriority journalQuestionnaireSelf report