2024-02-152024-02-152015-11-01Ocakoğlu, G. vd. (2015). "Statistical shape analysis of temporal lobe in mesial temporal sclerosis patients". Acta Neurochirurgica, 157(11), 1897-1903.0001-6268https://doi.org/10.1007/s00701-015-2555-9https://link.springer.com/article/10.1007/s00701-015-2555-9https://hdl.handle.net/11452/39767Surgery is regarded as a common treatment option for patients with mesial temporal lobe epilepsy due to hippocampal sclerosis but sometimes deciding this diagnosis can be very difficult. We aim to investigate the shape differences in the temporal lobe of mesial temporal sclerosis epilepsy patients compared with healthy controls, investigating the side difference and, if present, assessing the clinical application of this situation. The MRI scans of mesial TLE patients and controls were retrospectively reviewed. Temporal lobe data were collected from the two-dimensional digital images. Standard anthropometric landmarks were selected and marked on each digital image using TPSDIG 2.04 software. Eight anatomic landmarks were marked on images. A generalized Procrustes analysis was used to evaluate the shape difference. The shape deformation of the temporal lobe from control to patient was evaluated using the TPS method. There were statistically significant TL shape differences between groups. High level deformations for the left and right side from the control to patient group were seen in the TPS graphic. The highest deformation was determined at the inferior lateral temporal midpoint of the middle temporal gyri and superior temporal landmark points of both the right and left sides. Our study for the first time demonstrated temporal shape differences in TLE patients using a landmark-based geometrical morphometric method by taking into consideration the topographic distribution of TL.eninfo:eu-repo/semantics/closedAccessNeurosciences & neurologySurgeryMesial temporal lobeHippocampal sclerosisEpilepsyStatistical shape analysisHippocampal sclerosisEpilepsySurgeryAdolescentAdultAgedCase-control studiesData interpretation, statisticalEpilepsy, temporal lobeFemaleHippocampusHumansMagnetic resonance imagingMaleMiddle agedSclerosisTemporal lobeArticle0003629708000132-s2.0-84944160380189719031571126329731Neurosciences & neurologySurgeryCorpus callosum; Cerebrum; Magnetic resonance imagingCarbamazepineEtiracetamLamotrigineOxcarbazepineTopiramateZonisamideAdolescentAdultAnatomic landmarkArticleClinical articleClinical featureControlled studyFemaleHumanLeft hemisphereMaleMesial temporal lobe epilepsyNuclear magnetic resonance imagingPriority journalRetrospective studyRight hemisphereAgedCase control studyHippocampusMiddle agedPathologySclerosisStatistical analysisTemporal lobeTemporal lobe epilepsy