2022-03-222022-03-222013-11-15Şahin, S. vd. (2013). "Optimisation of ultrasonic-assisted extraction of antioxidant compounds from Artemisia absinthium using response surface methodology". Food Chemistry, 141(2), 1361-1368.0308-81461873-7072https://doi.org/10.1016/j.foodchem.2013.04.003https://pubmed.ncbi.nlm.nih.gov/23790925/http://hdl.handle.net/11452/25253Response surface methodology was used to optimise experimental conditions for ultrasonic-assisted extraction of phenolic compounds from Artemisia absinthium. The central composite design was employed, the extracts were characterised by the determination of total phenolic content and antioxidant capacity. The total phenolic contents of extracts were determined by Folin method and also total antioxidant capacities of extracts were determined by ABTS and CUPRAC methods. The phenolic compounds of A. absinthium at optimum extraction conditions were determined by HPLC-DAD. The optimum conditions were determined as HCl concentration between 0.41 and 0.44 mol/L, methanol volume between 55% and 59% (v/v), extraction temperature between 64 and 70 degrees C, extraction time between 101 and 107 min. The experimental values agreed with those predicted within a 95% confidence level, thus indicating the suitability of response surface methodology in optimising the ultrasound-assisted extraction of phenolic compounds from A. absinthium.eninfo:eu-repo/semantics/closedAccessChemistryFood science & technologyNutrition & dieteticsUltrasonic-assisted extractionArtemisia absinthiumResponse surface methodologyAntioxidant capacityPhenolic compoundsPeelL.CapacitySpicesAntioxidantsPhenolsSurface propertiesAntioxidant capacityArtemisia absinthiumPhenolic compoundsResponse surface methodologyUltrasonic-assisted extractionsExtractionArticle0003218035000952-s2.0-8487842351713611368141223790925Chemistry, appliedFood science & technologyNutrition & dieteticsArtemisia Absinthium; Beta-Thujone; Absinthe4 hydroxybenzoic acidAntioxidantArtemisia absinthium extractCaffeic acidCatechinChlorogenic acidCinnamic acidEllagic acidEpicatechinFerulic acidKaempferolKaempferol 3 beta d glucopyranosideLuteolinMethanolMyricetinPara coumaric acidPhenol derivativeProtocatechuic acidQuercetinRosmarinic acidRutosideSalicylic acidUnclassified drugAntioxidant activityArtemisia absinthiumArticleDry powderExtractionHigh performance liquid chromatographyNonhumanResponse surface methodTemperatureUltrasonic assisted extractionUltraviolet spectroscopy