2022-06-282022-06-282010-03-26Adım, Ş. B. vd. (2010). "Maspin expression in gastrointestinal stromal tumors". World Journal of Surgical Oncology, 8.1477-7819https://doi.org/10.1186/1477-7819-8-22https://wjso.biomedcentral.com/articles/10.1186/1477-7819-8-22http://hdl.handle.net/11452/27440Background: To investigate the role of maspin expression in the progression of gastrointestinal stromal tumors, and its value as a prognostic indicator. Methods: In the study 54 patients with GIST diagnosis were included in Uludag University of Faculty of Medicine, Department of Pathology between 1997-2007. The expression of maspin in 54 cases of gastrointestinal stromal tumor was detected by immunohistochemistry and compared with the clinicopathologic tumor parameters. Results: The positive expression rates for maspin in the GISTs were 66,6% (36 of 54 cases). Maspin overexpression was detected in 9 of 29 high risk tumors (31%) and was significantly higher in very low/low (78.6%) and intermediate-risk tumors (63.6%) than high-risk tumors. Conclusions: Maspin expression might be an important factor in tumor progression and patient prognosis in GIST. In the future, larger series may be studied to examine the prognostic significance of maspin in GISTs and, of course, maspin expression may be studied in different mesenchymal tumors.eninfo:eu-repo/semantics/openAccessParadoxical expressionP53 expressionGeneCarcinomaCancerAngiogenesisProgressionMammarySerpinCellsOncologySurgeryAdolescentAdultAgedDisease progressionFemaleGastrointestinal stromal tumorsHumansImmunoenzyme techniquesMaleMiddle agedNeoplasm stagingPrognosisRisk factorsSerpinsSurvival rateTumor markers, biologicalYoung adultArticle0002767600000012-s2.0-77952309178820346150OncologySurgerySERPIN-b5; Serine Proteinase Inhibitors; SerpinsMaspinSerine proteinase inhibitorSERPIN B5SERPIN-B5Tumor markerAcute pancreatitisAdolescentAdultAgedArticleCancer diagnosisCancer growthCancer localizationCancer riskControlled studyFemaleFollow upGastrointestinal stromal tumorHigh risk patientHumanHuman cellImmunohistochemistryMajor clinical studyMaleMetastasisOverall survivalPrognosisProtein expressionSurvival rateTumor growthCancer stagingDisease courseEnzyme immunoassayGastrointestinal stromal tumorMetabolismMiddle agedPathologyRisk factor