2023-01-162023-01-162017-02-20Yılmaz, C. vd. (2017). ''Low serum IGF-1 and increased cytokine levels in tracheal aspirate samples are associated with bronchopulmonary dysplasia''. Turkish Journal of Pediatrics, 59(2), 122-129.0041-4301https://doi.org/10.24953/turkjped.2017.02.003http://www.turkishjournalpediatrics.org/abstract.php?id=1692http://hdl.handle.net/11452/30476Despite developments in the perinatal and neonatal care, bronchopulmonary dysplasia (BPD) is still the most frequently seen long-term complication in preterm infants. The aim of this prospective study is to investigate the association between the development of BPD and serial measurements of IGF-1 levels and their relationship with levels of IGF-1 and cytokine in tracheal aspirate fluids. A total of 40 premature infants, born at a gestational age of <= 32 weeks, were enrolled in the study. On postnatal day-1, 3, 7, 21 and 28 serum IGF-1 levels and IGF-1 levels, IL-6, IL-8, IL-10 and TNF-alpha levels in tracheal aspirate fluid samples of intubated cases were examined. Mean gestational age of 40 patients included in the study was 29.41 +/- 2.23 weeks, and their mean birth weight was 1,256.85 +/- 311.48 g. BPD was detected in 35% of cases. Mean gestational week and birth weight of the cases that developed BPD were 30 +/- 3 weeks and 1,150 +/- 295 g, respectively. Serum IGF-1 levels on postnatal day-1, 3, 7, 21 and 28 in cases who developed BPD were significantly lower when compared with those without BPD (p<0.01). Levels of IL-6, IL-8, IL-10, and TNF-alpha in tracheal aspirate samples were significantly higher in cases with BPD compared to those without BPD (p<0.05). IGF-1 levels in tracheal aspirate fluid samples did not differ significantly based on the presence of BPD (p>0.05). Severity of BPD was associated with decreased serum IGF-1 levels and increased cytokine levels in tracheal aspirate samples.eninfo:eu-repo/semantics/openAccessPediatricsBronchopulmonary dysplasiaCytokinesPrematureTracheal aspirate fluidIGF-1Chronic lung-diseaseBirth-weight infantsRespiratory-distress-syndromeBronchoalveolar lavage fluidNecrosis-factor-alphaGrowth-factor-IPremature-infantsPreterm infantsIl-8 expressionComplicationsBiomarkersBirth weightBronchopulmonary dysplasiaCytokinesFemaleGestational ageHumansInfantNewbornPrematureInsulin-like growth factor IMalePrognosisProspective studiesSeverity of illness indexTracheaArticle0004229673000032-s2.0-8504082474312212959229276864PediatricsBronchopulmonary Dysplasia; Chorioamnionitis; LungCytokineInterleukin 10Interleukin 6Interleukin 8Somatomedin CTumor necrosis factorBiological markerCytokineIGF1 protein, humanSomatomedin CArticleBirth weightBlood samplingBody fluidClinical articleDisease associationDisease severityFemaleGestational ageHospitalized childHumanLung dysplasiaMaleNewbornPredictive valuePrematurityProspective studyReceiver operating characteristicSensitivity and specificityTracheal aspirate fluidLung dysplasiaMetabolismPrematurityPrognosisSeverity of illness indexTrachea