2021-11-222021-11-222006Başkan, E. B. vd. (2006). ''A case of epidermodysplasia verruciformis associated with squamous cell carcinoma and Bowen's disease: A therapeutic challenge''. Journal of Dermatological Treatment, 17(3), 179-183.0954-66341471-1753https://doi.org/10.1080/09546630600788844https://www.tandfonline.com/doi/full/10.1080/09546630600788844http://hdl.handle.net/11452/22761Epidermodysplasia verruciformis (EV) is a very rare and chronic disease characterized by a susceptibility to cutaneous infections by a group of phylogenetically related human papillomavirus (HPV) types. We present here a 52-year-old man previously diagnosed and treated as squamous cell carcinoma but also found to have epidermodysplasia verruciformis lesions in association with Bowen's disease. The patient was effectively treated with a combination of interferon therapy (6 million units, twice a week) and topical imiquimod for Bowen's disease (five times a week). We conclude that topical imiquimod is very effective in the treatment of Bowen's disease and may be combined with systemic interferon therapy in rare cases with multiple vivid presentations of HPV infections.eninfo:eu-repo/semantics/closedAccessDermatologySquamous cell carcinomaInterferon alphaImiquimodEpidermodysplasia verruciformisBowen's diseaseHuman papillomavirusesDNAImiquimod 5-percent creamAcitretinImmunodeficiencyCombinationImmunotherapySkin neoplasmsScalpMiddle agedMaleInterferonsHumansEpidermodysplasia verruciformisDrug therapy, combinationDiagnosis, differentialCarcinoma, squamous cellBowen's diseaseAntineoplastic agentsAminoquinolinesAdministration, cutaneousArticle0002391949000122-s2.0-3374660814117918317316854762DermatologyEpidermodysplasia Verruciformis; Betapapillomavirus; Skin NeoplasmsImiquimodAlpha interferonWart virusVirus infectionSymptomSquamous cell carcinomaActinic keratosisSkin biopsyAdultPunch biopsyPriority journalPhylogenyMaleInfection sensitivityHuman tissueHumanHistopathologEpidermodysplasia verruciformisDrug efficacyDrug effectDisease associationClinical featureCase reportBowen diseaseArticle