2022-03-142022-03-142010-12Karkucak, M. vd. (2010). "Prenatal diagnosis of de novo reciprocal translocation t(1;12)(q21.3;p11.2) with trisomy 21 and sperm FISH analysis for increased aneuploidy risk". International Journal of Human Genetics, 10(4), 231-234.0972-3757https://doi.org/10.1080/09723757.2010.11886110https://www.tandfonline.com/doi/abs/10.1080/09723757.2010.11886110http://hdl.handle.net/11452/24978Complex rearrangements such as de novo translocations together with aneuploidy are unusual situations in prenatal diagnosis. We report a case with de novo translocation t(1;12)(q21.3;p11.2) and trisomy 21. Father's sperm was analyzed for potential of increased risk of aneuploidy. Results showed no paternal increased risk for chromosomes 13, 18, 21, X, Y. Based on our results, we suggest that possible increased maternal aneuploidy risk add other possible mechanisms should be investigated to better understand cell division errors and to give better genetic counseling.eninfo:eu-repo/semantics/closedAccessPrenatal diagnosisTranslocationAneuploidySperm FISHGenetic counselingIn-sıtu hybridizationConstitutionalRearrangementsChromosomal-aberrationsFragile sitesCarriersBreakpointsAmniocentesisGenetics & heredityArticle0002873404000042-s2.0-79953273937231234104Genetics & heredityWolf-Hirschhorn Syndrome; Phenotype; EF Hand MotifAdultAneuploidyArticleCase reportChromosome 11pChromosome 13Chromosome 18Chromosome 21Chromosome 21qChromosome G bandChromosome polymorphismChromosome translocation 1Chromosome translocation 12FemaleFluorescence in situ hybridizationGenetic associationGenetic riskGenetic screeningHumanKaryometryKaryotype 47,XXXMalePrenatal diagnosisReciprocal chromosome translocationRisk assessmentSemen analysisTrisomy 21X chromosomeY chromosome