2022-04-282022-04-282003Özuysal, S. vd. (2003). “Angiogenesis in endometrial carcinoma: Correlation with survival and clinicopathologic risk factors”. Gynecologic and Obstetric Investigation, 55(3), 173-177.0378-7346https://doi.org/10.1159/000071533https://www.karger.com/Article/Abstract/71533http://hdl.handle.net/11452/26240Association among angiogenesis, survival and clinicopathologic parameters in endometrial carcinoma was evaluated. Sixty patients who had been diagnosed as endometrial carcinoma, from 1993 to 1998, were included in the study. All patients had been surgically staged with bilateral pelvic and para-aortic lymph node dissection. All hysterectomy specimens were stained immunohistologically for factor VIII-related antigen. The area with the most intensified microvasculature was determined under low-power (x 100) magnification, and the microvessel count of this area under high-power (x 200) magnification was determined as the microvessel density (MVD) of the tumor. The mean MVD was 26.2 +/- 13.0 (range 6-68), and it was considered as high (n = 24; 40%), moderate (n = 19; 31.7%) and low (n = 17; 28.3%) when the MVD was >30, between 15-30 and <15, respectively. Statistical analysis included Mann-Whitney, Kruskal-Wallis and Spearman rank correlation tests. The Kaplan-Meier method was used to evaluate the difference between angiogenesis and survival. Multivariate analysis with the Cox regression model was used in MVD values and different clinicopathological parameters. There was positive correlation between MVD increase and surgicopathological stage (p < 0.05). A significant difference was seen between MVD increase and lymph node metastasis (p < 0.05). There were no differences between MVD and age, histological type, grade and lymphovascular invasion. MVD did not change in association with myometrial invasion depth. There was a significant difference in means of survival between the low and high MVD groups (p = 0.01). However, MVD was not an independent prognostic factor in multivariate analysis. Increased angiogenesis was found to be associated with advanced stage and decreased survival in endometrial carcinoma.eninfo:eu-repo/semantics/closedAccessObstetrics and gynecologyEndometrial cancerAngiogenesisMicrovessel densitySurvivalPrognosisTumor angiogenesisBreast-carcinomaPrognostic-significanceMicrovessel densityGrowth-factorExpressionMetastasisCancerIndicatorAdenocarcinomaAgedCarcinoma, endometrioidCystadenocarcinoma, papillaryEndometrial neoplasmsFemaleHumansLymphatic metastasisMiddle agedMyometriumNeoplasm invasivenessNeoplasm recurrence, localNeoplasm stagingNeovascularization, pathologicOvarian neoplasmsPrognosisRisk factorsSurvival rateArticle0001843423000102-s2.0-004274402117317755312865598Obstetrics and gynecologyMicrovasculature; Angiogenesis; CancerAgeAnalytic methodAngiogenesisArticleCancer invasionCancer riskCancer stagingCancer surgeryCancer survivalCorrelation analysisDensityDiagnostic imagingDisease associationDisease severityEndometrium carcinomaEvaluationFemaleHistopathologyHumanHuman tissueHysterectomyImage analysisImmunohistochemistryKruskal wallis testLymph node dissectionLymph node metastasisLymph vesselMajor clinical studyMicrovasculatureMultivariate analysisMyometriumParaaortic lymph nodeParameterPathophysiologyPelvis lymph nodePriority journalPrognosisRank sum testRegression analysisRisk assessmentRisk factorStatistical analysisStatistical modelSurvival rateTissueTumor vascularizationVon willebrand factor