2021-11-192021-11-192000Karacalar, A. vd. (2000). "Effect of surgical denervation on the viability of inferior epigastric neurovenous flaps in the rat". Annals of Plastic Surgery, 45(3), 298-304.0148-7043https://doi.org/10.1097/00000637-200045030-00013https://journals.lww.com/annalsplasticsurgery/Citation/2000/45030/Effect_of_Surgical_Denervation_on_the_Viability_of.13.aspxhttp://hdl.handle.net/11452/22736The purpose of this study was to examine how the inferior epigastric neurovenous flap in the rat reacts to surgical denervation, The survival of a denervated flap was compared with that of an innervated flap. A 2 x 2-cm flap was raised in 30 female Wistar rats assigned randomly to six groups of 10 rats each: group 1, innervated neurovenous flap; group 2, denervated neurovenous flap, acute model; group 3, denervated neurovenous flap, chronic model; group 4, innervated inferior epigastric island flap; group 5, denervated inferior epigastric island flap, acute model; and group 6, control, composite graft. Acute denervation produced a significant decrease in the survival of the inferior epigastric neurovenous flap (p < 0.05), The surviving area of the innervated flaps decreased from 94 +/- 14% (mean +/- standard deviation) to 16 +/- 34% by acute denervation, Chronic denervation was effective in decreasing flap necrosis in these flaps (survival, 99 +/- 5%), There were no differences between the average viable area of the standard inferior epigastric flap in the denervated and innervated groups.eninfo:eu-repo/semantics/closedAccessSurgeryMuscleModelArticle0000891782000132-s2.0-003381139729830445310987533SurgeryParental Separation; Neonatal Intensive Care Units; Early LifeAnimal tissueArticleControlled studyDenervationExperimental modelExperimental surgeryFemaleGraft survivalHistopathologyNeurovascular island flapNonhumanPriority journalRatStomachTissue necrosisVein