Sudha, ThangiralaBharali, Dhruba J.Darwish, Noureldien H. E.Keating, Kelly A.Lin, Hung-YunDavis, Paul J.Mousa, Shaker A. Shaker A.2022-12-222022-12-222017Sudha, T. vd. (2017). ''Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac''. International Journal of Nanomedicine, 12, 1305-1315.1178-2013https://doi.org/10.2147/IJN.S123742https://www.dovepress.com/targeted-delivery-of-paclitaxel-and-doxorubicin-to-cancer-xenografts-v-peer-reviewed-fulltext-article-IJNhttp://hdl.handle.net/11452/30051NanoPharmaceuticals LLC (Rensselaer, NY, USA)The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin alpha v beta 3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P < 0.001) and 2.3-fold (doxorubicin; P < 0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy.eninfo:eu-repo/semantics/openAccessScience & technology - other topicsPharmacology & pharmacyDoxorubicinIntegrinNanoparticleNanotetracNDATPaclitaxelTetraiodothyroacetic acidXenograftsActivated protein-kinaseTetraiodothyroacetic acidThyroid-hormoneIn-vitroCo-deliveryCellsNanomedicineReceptorGrowthCisplatinAnimalsAntineoplastic agentsBreast neoplasmsCell line, tumorCell survivalDoxorubicinDrug delivery systemsDynamic light scatteringFemaleHumansLactic acidMice, nudeNanoparticlesPaclitaxelPancreatic neoplasmsParticle sizePolyglycolic acidThyroxineXenograft model antitumor assaysArticle0003940484000022-s2.0-85013472911130513151228243091Nanoscience & nanotechnologyPharmacology & pharmacyIntegrin; Thyroid Hormones; Nano-Diamino-TetracDiamino tetraiodothyroacetic acid nanoparticleDocetaxelDoxorubicinNanoparticlePaclitaxelUnclassified drugAntineoplastic agentDoxorubicinLactic acidNanoparticlePaclitaxelPolyglycolic acidPolylactic acid-polyglycolic acid copolymerTetraiodothyroacetic acidThyroxineAnimal cellAnimal experimentAnimal modelAnimal tissueAntineoplastic activityArticleBreast cancerCell viabilityControlled studyDrug adsorptionDrug delivery systemDrug efficacyDrug formulationDrug uptakeEx vivo studyFemaleMouseNanoencapsulationNonhumanPancreas cancerParticle sizeTumor volumeAnalogs and derivativesAnimalBreast NeoplasmsCell survivalChemistryDrug effectsDrug screeningHumanNude mousePancreatic NeoplasmsPhoton correlation spectroscopyTumor cell lineIn vivo study