2022-03-162022-03-162010-02Gülten, T. vd. (2010). "5′ MLL gene deletion in a case with childhood acute lymphoblastic leukemia". Laboratory Medicine, 41(2), 83-86.0007-5027https://doi.org/10.1309/LMC5LW0IMKNG5LCNhttps://academic.oup.com/labmed/article/41/2/83/2504871http://hdl.handle.net/11452/25089Myeloid/lymphoid leukemia (MLL) gene rearrangements are high risk cytogenetic characteristics of acute lymphoblastic leukemia (ALL). Translocations of this gene are well defined, and their impact on the patient's prognosis is well known, but deletions of the same region are rare, and little is known about their prognostic significance and the significance of their accompanying translocations. Here we present a case of childhood ALL with a deletion of the 5' region of the MILL gene detected by fluorescence in situ hybridization (FISH) analysis, This result also confirmed the sensitivity and efficiency of FISH analysis.eninfo:eu-repo/semantics/openAccessMLL gene deletionAcute Lymphoblastic LeukemiaFISH analysisHemotological malignanciesRearrangementTranslocationsIdentificationAbnormalitiesAberrationsApoptosis11Q23ProbeFishMedical laboratory technologyArticle0002739408000032-s2.0-779519495448386412Medical laboratory technologyEPZ-5676; Myeloid-Lymphoid Leukemia Protein; Acute Lymphoblastic LeukemiaAcute lymphocytic leukemiaArticleCase reportChildChildhood leukemiaCytogeneticsFluorescence in situ hybridizationGene deletionGene rearrangementGene translocationHumanMaleMll geneOncogenePreschool childPrognosisSensitivity and specificity