2024-09-232024-09-232018-06-012564-6850https://doi.org/10.5152/turkjsurg.2017.3279https://hdl.handle.net/11452/45063The coexistence of signet-ring cell carcinoma and neuroendocrine tumors is very rare. We report a 57-year-old man who presented with a history of weight loss and nausea. Gastric mucosal biopsies obtained during gastrointestinal endoscopy revealed a gastric signet-ring cell carcinoma. The patient underwent a total gastrectomy with a standard D2 lymph node dissection. Ten individual tumors were detected in the resected specimen. Based on the histopathological and immunohistochemical findings, the final diagnosis was co-existing signet-ring cell carcinoma and neuroendocrine tumor. Spindle-shaped cells and extracytoplasmic mucin were noted in some tumor cells forming the neuroendocrine component. This case is a rare synchronous tumor because of its unusual neuroendocrine component.eninfo:eu-repo/semantics/closedAccessStomachSynchronousGastricMucin-producingSpindleNeuroendocrine tumorScience & technologyLife sciences & biomedicineSurgeryArticle00044030450001815215434210.5152/turkjsurg.2017.3279