Demir, KorcanDöneray, HakanKara, CengizAtay, ZeynepÇetinkaya, Semra ÇaǧlarÇayır, AtillaAnık, AhmetUçaktürk, Seyit AhmetYılmaz, Gülay CanErgür, Ayça TörelKendirci, MustafaAycan, ZehraBereket, AbdullahAydın, MuratOrbak, ZerrinÖzkan, Behzat2024-01-092024-01-092018-10-23Eren, E. vd. (2018). "Comparison of treatment regimens in management of severe hypercalcemia due to vitamin D intoxication in children". JCRPE Journal of Clinical Research in Pediatric Endocrinology, 11(2), 140-148.1308-57271308-5735https://doi.org/10.4274/jcrpe.galenos.2018.2018.0131https://cms.galenos.com.tr/Uploads/Article_19904/JCRPE-11-140-En.pdfhttps://hdl.handle.net/11452/38873Objective: No large study has been conducted to date to compare the effectiveness of prednisolone, alendronate and pamidronate as first-line treatment in children with hypercalcemia due to vitamin D intoxication. The aim was to perform a multicenter, retrospective study assessing clinical characteristics and treatment results. Methods: A standard questionnaire was uploaded to an online national database system to collect data on children with hypercalcemia (serum calcium level > 10.5 mg/dL) due to vitamin D intoxication [serum 25-hydroxyvitamin D (25(OH)D) level > 150 ng/mL] who were treated in pediatric endocrinology clinics. Results: Seventy-four children [median (range) age 1.06 (0.65-1.60) years, 45 males (61 %) from II centers] were included. High-dose vitamin D intake was evident in 77% of the cases. At diagnosis, serum calcium, phosphorus, alkaline phosphatase, 25(OH)D and parathyroid hormone concentrations were 15 +/- 3.2 mg/dl., 5.2 +/- 1.2 mg/dL, 268 +/- 132 IU/L, 322 (236-454) ng/ml, and 5.5 (3-10.5) pg/mL, respectively. Calcium levels showed moderate correlation with 25(OH)D levels (r(s) = 0.402, p <0.001). Patients were designated into five groups according to the initial specific treatment regimens (hydration-only, prednisolone, alendronate, pamidronate, and combination). Need for another type of specific drug treatment was higher in children who initially received prednisolone (p <0.000). Recurrence rate of hypercalcemia was significantly lower in children who were treated with pamidronate (p=0.02). Conclusion: Prednisolone is less effective in the treatment of children with severe hypercalcaemia secondary to vitamin D intoxication and timely implementation of other treatment regimens should be considered.eninfo:eu-repo/semantics/openAccessNutritionStoss therapyOver-the-counter drugsSteroidRicketsD deficiencyTherapyInfantsPamidronateToxicityAlendronatePreventionRiskEndocrinology & metabolismPediatricsBone density conservation agentsFemaleFollow-up studiesHumansHypercalcemiaInfantMalePamidronatePrognosisRetrospective studiesVitamin dVitaminsArticle0004692711000052-s2.0-8506730176514014811230396880Endocrinology & metabolismPediatricsOsteoporosis; Kidney Transplantation; Bone DensityArticleCalcium blood levelCerebral palsyChildConstipationDrug efficacyEpilepsyFemaleFollow upHemodialysisHumanHydrationHypercalcemiaHypercalciuriaInfantKidney calcificationLoss of appetiteMajor clinical studyMaleMeningomyeloceleNephrolithiasisPreschool childQuestionnaireRetrospective studySchool childVitamin d deficiencyVitamin d intoxicationVomitingBloodClinical trialComparative studyHypercalcemiaMulticenter studyPathologyPrognosis25 hydroxyvitamin dAlendronic acidAlkaline phosphataseCalciumFurosemidePamidronic acidParathyroid hormonePhosphorusPrednisoloneVitamin dBone density conservation agentVitaminVitamin d