2021-09-132021-09-132006Taş, S. vd. (2006). ''The effect of taurine supplementation on oxidative stress in experimental hypothyroidism''. Cell Biochemistry and Function, 24(2), 153-158.0263-64841099-0844https://doi.org/10.1002/cbf.1198https://onlinelibrary.wiley.com/doi/10.1002/cbf.1198http://hdl.handle.net/11452/21918The purpose of this study was to investigate the oxidative status in experimental hypothyroidism and the antioxidant effect of taurine supplementation. Forty male Sprague Dawley rats were randomly divided into four groups (group 1, control; group 2, control + taurine; group 3, propylthiouracil (PTU); group 4, PTU + taurine). Hypothyroidism was induced by giving 0.05% PTU in drinking water for 8 weeks. Taurine was supplemented in drinking water at a concentration of 1 % for 5 weeks. Plasma (p < 0.05), red blood cell (p < 0.01), liver (p < 0.001) and kidney tissue (p > 0.05) malondialdehyde levels were increased in the PTU group compared with those of the control rats and were decreased in the PTU + taurine group compared with the PTU alone group. No significant changes were observed in glutathione levels of kidney and liver in the PTU group, but taurine supplementation significantly increased the glutathione levels of these tissues. Paraoxonase and arylesterase activities were decreased in the PTU group while taurine supplementation caused no significant changes in paraoxonase and arylesterase activities. These findings suggest that taurine supplementation may play a protective role against the increased oxidative stress resulting from hypothyroidism.eninfo:eu-repo/semantics/closedAccessBiochemistry & molecular biologyCell biologyTaurineRatOxidative stressHypothyroidismSerumParaoxonaseSkeletal-muscleEnzyme-activitiesEnzyme-activitiesLiver-mitochondriaThyroid-dysfunctionAntioxidant defenseRat hepatocytesLipid-peroxidationHepatic glutathione synthesisArticle0002363996000102-s2.0-3364532028515315824215617030Cell biologyBiochemistry & molecular biologyHyperthyroidism; Propylthiouracil; Levothyroxine Sodium