2024-02-272024-02-272008-04Baran, B. vd. (2008). "Acute myocardial infarction, ischemic cerebrovascular disease and variceal bleeding due to portal vein thrombosis in a patient with hereditary thromblophilia". Blood Coagulation and Fibrinolysis, 19(3), 243-246.0957-52351473-5733https://doi.org/10.1097/MBC.0b013e3282f30ae5https://journals.lww.com/bloodcoagulation/Fulltext/2008/04000/Acute_myocardial_infarction,_ischemic.12.aspxhttps://hdl.handle.net/11452/39989We report On a 43-year-old female patient with multiple thrombotic risk factors who, in a few months, developed acute myocardial infarction, an ischemic cerebrovascular event and variceal bleeding due to portal vein thrombosis. The factor V Leiden mutation was carried in heterozygous form, homocysteine was elevated at 19.6 mu mol/l, and methylene-tetrahydrofolate reductase C677T mutation was carried in. homozygous form. Moderately increased plasma homocysteine level and a reduced protein S activity were evident. Anticardiolipin IgG antibodies were mildly positive. We conclude that the presence of multiple genetic and environmental risk factors greatly amplifies the risk of clinical thrombotic events.eninfo:eu-repo/semantics/closedAccessFactor V Leiden mutationHereditary thrombophiliaMethylenetetrahydrofolate mutationPortal vein thrombosisFactor-v-leidenVenous thrombosiAntiphospholipid antibodiesCirrhotic-patientsRiskMetaanalysisDisordersMutaionMthfrThromboembolismHematologyAdultFactor VFemaleGenetic predisposition to diseaseHumansMethylenetetrahydrofolate reductase (nadph2)Myocardial infarctionPortal veinStrokeThrombophiliaVenous thrombosisArticle0002552283000122-s2.0-4184913286324324619318388507HematologyMutation; Prothrombin; Activated Protein C Resistance5,10 methylenetetrahydrofolate reductase (FADH2)Acetylsalicylic acidBlood clotting factor 5 LeidenCardiolipin antibodyCarvedilolClopidogrelEsomeprazoleHomocysteineImmunoglobulin G antibodyIsosorbide mononitrateLansoprazoleLow molecular weight heparinNadroparinPravastatinProtein SProton pump inhibitorAcute heart infarctionAdultArticleBleedingCase reportCerebrovascular accidentCoronary stentDrug substitutionDrug withdrawalEnvironmental factorFemaleGene mutationGenetic riskHeterozygosityHomozygosityHumanPercutaneous coronary interventionPortal vein thrombosisPortal vein thrombosisProtein functionRisk factorThrombophiliaThrombosisUpper gastrointestinal bleedingVarix bleeding