Özkan, S.2022-03-302022-03-302003-01Durak, K. vd. (2003). “Histological assessment of the effect of alpha-tocopherol on fracture healing in rabbits”. Journal of International Medical Research, 31(1), 26-30.0300-0605https://doi.org/10.1177/147323000303100104https://journals.sagepub.com/doi/10.1177/147323000303100104http://hdl.handle.net/11452/25432To investigate the effect of alpha-tocopherol (vitamin E) on fracture healing in rabbits, two groups of 10 rabbits were either injected with alpha-tocopherol (treated) or untreated (controls). The right femurs of both groups were fractured, and the treated group were injected intramuscularly with 20 mg/kg alpha-tocopherol daily for 5 days starting on the day of fracture. After 21 days, histological sections of the fractured region were examined and scored. Fracture healing had progressed further in the alpha-tocopherol group than in the control group. A statistically significant difference between the histological grading of fracture healing in the two groups was found. This difference may result from an antioxidant (alpha-tocopherol) effect on free oxygen radicals in the fracture area. We conclude that alpha-tocopherol may affect fracture healing favourably and might be useful as a therapeutic agent in clinical fracture management.eninfo:eu-repo/semantics/openAccessResearch and experimental medicinePharmacology and pharmacyAlpha-tocopherolVitamin EAntioxidantFracture healingRabbitHistological assessmentOxygen-free-radicalsVitamin-CTissueArticle0001812913000042-s2.0-0037226366263031112635530Medicine, research and experimentalPharmacology and pharmacyFracture Healing; Ovx; OsteoporosisAnimal experimentAnimal modelAnimal tissueArticleControlled studyDose responseDrug effectDrug useFemur fractureFracture healingHistopathologyMaleNonhumanRabbitScoring systemStatistical analysisTissue sectionAlpha tocopherolAntioxidantFree radicalOxygen