Buz, Pelin TurhanDuman, Fatma DemirErkisa, MerveDemirci, GözdeUlukaya, EnginAcar, Havva Yağcı2024-02-122024-02-122019-04Buz, P. T. vd. (2019). ''Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect''. Nanomedicine, 14(8), 969-988.1743-58891748-6963https://doi.org/10.2217/nnm-2018-0214https://hdl.handle.net/11452/39618Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their optical imaging potential and toxicity were studied in vitro. Results: NAC-Ag2S QDs have strong emission, that is tunable between 748 and 840 nm, and are stable in biologically relevant media. QDs showed significant differences both in cell internalization and toxicity in vitro. QDs were quite toxic to breast and cervical cancer cells but not to lung derived cells despite the higher uptake. NAC-Ag2S reduces reactive oxygen species (ROS) but causes cell death via DNA damage and apoptosis. Conclusion: NAC-Ag2S QDs are stable and strong signal-generating theranostic agents offering selective therapeutic effects.eninfo:eu-repo/semantics/openAccessBiotechnology & applied microbiologyScience & technology - other topicsAg2S quantum dotsApoptosisDNA damageImagingN-acetyl-L-cysteine (NAC)Reactive oxygen species (ROS)Dna-damageHighly luminescentAcetylcysteine nacOxidative stressApoptosisGlutathioneInductionToxicityGrowthNanoparticlesAcetylcysteineAntineoplastic agentsApoptosisBiological transportCell line, tumorCell survivalDNA damageFree radical scavengersHumansInfrared raysLuminescenceLuminescent agentsNeoplasmsOxidative stressParticle sizeQuantum dotsReactive oxygen speciesSilver compoundsSurface propertiesArticle0004726800000042-s2.0-8506455488196998814830917096Biotechnology & applied microbiologyNanoscience & nanotechnologyNanocrystal; Cdte; Forster Resonance Energy TransferAcetylcysteineQuantum dotReactive oxygen metaboliteSilver derivativeSilver sulfideWaterUnclassified drugAcetylcysteineAntineoplastic agentLuminescent agentQuantum dotReactive oxygen metaboliteScavengerSilver derivativeSilver sulfideApoptosisArticleBreast cancer cell lineCell deathCervical cancer cell lineControlled studyDNA damageDrug stabilityDrug synthesisFluorescence imagingIn vitro studyLung alveolus cellPhagocytosisPriority journalTherapy effectCell survivalChemistryDiagnostic imagingDrug effectHumanInfrared radiationLuminescenceMetabolismNeoplasmOxidative stressParticle sizeSurface propertyTransport at the cellular levelTumor cell line