Armutak, Elif İlkayAkgün, Kadriye DarKapucu, AyşegülOsanç, EsmaDoğruman, HüsniyeEraltan, Hakan2021-12-072021-12-072009-12Armutak, E. İ. vd. (2009). "Apoptosis-inducing effects of morinda citrifolia l. and doxorubicin on the ehrlich ascites tumor in balb-c mice". Cell Biochemistry and Function, 27(8), 542-546.0263-6484https://doi.org/10.1002/cbf.1604https://onlinelibrary.wiley.com/doi/10.1002/cbf.1604http://hdl.handle.net/11452/23042Morinda citrifolia L. (Noni) is, a herbal remedy with promising anti-cancer properties. However, its effects on various, cancers are to be investigated to make a firm conclusion before implementing it into the clinical practice. Therefore, we investigated the cytotoxic potential of noni on Ehrlich ascites tumor grown in female Balb-c mice and also combined it with I potent anti-cancer agent, doxorubicin One group received noni only (n = 8). another one doxorubicin (n. = 8). and the other one noni + doxorubicin (n = 8) for 14 days after the inoculation of cells. The control group (n = 7) received 0.9% NaCl only. We found that short and long diameters of the tumor tissues were about 40-50% smaller, compared to those in control group This anti-growth effect resulted from the induction of apoptosis, which was confirmed by the positive results from the Terminal Deoxynucleotidyl Transferase dUTP Nick End Labeling (TUNEL) analysis and the active caspase-3 cells in tissues Apoptosis also confirmed by caspase-derived cytokeratin 18 elevation in serum of the treated groups. Further, the proliferation was decreased, which was immunohistochemically shown by the PCNA staining. We conclude that noni may be usefull in the treatment of breast Cancer either on its own or in combination with doxorubicin. Further studies are warranted to assess the dosage and safely of using noni fruit juice in conjuction with anti-cancer drugs against breast cancer.eninfo:eu-repo/semantics/closedAccessMorinda citrifolia l. noniApoptosisProliferationCancerMiceIn vivoPolysaccharide-rich substanceFruit juiceNoniCytokeratin-18CancerCarcinomaSerumBiochemistry & molecular biologyCell biologyMorinda citrifoliaMusAnimalsApoptosisBreast neoplasmsCarcinoma, ehrlich tumorCaspase 3Disease models, animalDoxorubicinDrug evaluation, preclinicalDrug therapy, combinationFemaleHumansMiceMice, inbred BALB CMorindaPlant extractsRandom allocationArticle0002725768000062-s2.0-7194908305754254627819908222Biochemistry & molecular biologyCell biologyMorinda Citrifolia; Damnacanthal; Fruit and Vegetable JuicesAlnoniCaspase 3CyclineCytokeratin 18DoxorubicinMorinda citrifolia extractUnclassified drugAnimal experimentAnimal modelAnimal tissueApoptosisArticleCancer inhibitionCell proliferationControlled studyCytotoxicityDrug effectDrug efficacyDrug potentiationEhrlich ascites tumorFemaleImmunohistochemistryMonotherapyMorinda citrifoliaMouseNick end labelingNonhumanPriority journalProtein blood level cell proliferationControlled studyCytotoxicityDrug effectDrug efficacyDrug potentiationEhrlich ascites tumorFemaleImmunohistochemistryMonotherapyMorinda citrifoliaMouseNick end labelingNonhumanPriority journalProtein blood level