Sevimli, AlperUğuz, Cevdet2021-08-312021-08-312005-04Sevimli, A. vd. (2005). "The effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy in brown layer chicks". Avian Pathology, 34(2), 143-149.0307-94571465-3338https://doi.org/10.1080/03079450500059149https://www.tandfonline.com/doi/full/10.1080/03079450500059149http://hdl.handle.net/11452/21585The effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy were investigated. In this study, 175 1-day-old brown layer chicks were used. Throughout the study Group II ( vitamin A) received high doses of vitamin A ( 75 000 IU/kg), whereas Group I ( negative control), Group III ( positive control), Group IV ( pentoxyfylline) and Group V ( methylprednisolone) received normal levels of vitamin A in the diet. At the fifth week, the experimental Groups II, III, IV and V were injected with Freund's adjuvant intra-articularly to induce amyloid arthropathy. Group IV received pentoxyfylline and Group V received methylprednisolone ( 10 mg/kg, intramuscularly) once. Joint and blood samples were examined 13 weeks after the injections. The values in Groups I, II, III, IV and V, respectively, were as follows: amyloid arthropathy formation (%), 0, 100, 87, 76, 66; serum amyloid A (ng/ml), 1669/17, 607 +/- 40, 423 +/- 39, 342 +/- 27, 293 +/- 22; serum retinol (mu g/dl): 59.75 +/- 3.8, 42.72 +/- 3, 59.24 +/- 3.6, 102 +/- 9.1, 101.3 +/- 12.3; heterophil/lymphocyte ratio: 0.504, 0.75, 0.75, 0.087, 0.44. In conclusion, it was observed that vitamin A enhanced the development of amyloid arthropathy and there were positive associations between amyloidosis, increased levels of serum amyloid A and increased numbers of tissue infiltrating macrophages. Methylprednisolone had a more successful inhibitory effect on amyloid arthropathy than pentoxyfylline.eninfo:eu-repo/semantics/openAccessAcute-Phase ProteinNf-Kappa-BRetinoic acidPrecursor proteinGene-expressionPhorbol esterInterleukin-1ActivationInhibitionBindingVeterinary sciencesGallus gallusAmyloidosisAnimalsAnti-inflammatory agentsChickensEnzyme inhibitorsFreund's adjuvantJoint diseasesMethylprednisolonePentoxifyllinePoultry diseasesVitamin AArticle0002288348000112-s2.0-1784440483514314934216191696Veterinary sciencesSerum Amyloid A Protein; Amyloidosis; Amyloid Enhancing FactorAntiinflammatory agentEnzyme inhibitorFreund adjuvantMethylprednisolonePentoxifyllineRetinolAmyloidosisAnimalAnimal diseaseArthropathyBird diseaseChemically induced disorderChicken