2022-08-122022-08-122015-01-30Alpay, G. ve Yeşilbağ K. (2015). "Serological relationships among subgroups in bovine viral diarrhea virus genotype 1 (BVDV-1)". Veterinary Microbiology, 175(1), 1-6.0378-11351873-2542https://doi.org/10.1016/j.vetmic.2014.10.034https://www.sciencedirect.com/science/article/pii/S0378113514005124http://hdl.handle.net/11452/28188Bovine viral diarrhea virus (BVDV) has various economic impacts associated with diarrhea, poor performance, an increase in the frequency of other infections and lethal outcomes. Both genotypes, namely BVDV-1 and BVDV-2, as well as different subgroups within these genotypes have been reported worldwide. Understanding the serological differences among the BVDV subgroups is important for disease epidemiology and prevention as well as vaccination programs. The aim of this study was to determine the serological relatedness among the subgroups in BVDV-1. For that purpose, sheep hyperimmune sera were collected against representative strains from 6 of the subgroups of BVDV-1 (BVDV-1a, -1b, -1d, -1f, -1h and -1l). The serum samples that gave the peak antibody titer to the homologous strains were used to perform cross neutralization assays. The highest homologous antibody titer (1:5160) was obtained against BVDV-1h. Regarding the cross neutralizing (heterologous) antibodies, the lowest titer (1:20) was produced by the BVDV-1f antiserum against the BVDV-1a and BVDV1-b viruses. The highest cross neutralizing titer (1:2580) achieved by the BVDV-1h antiserum was against the BVDV-1b strain. The cross neutralization results indicated particular serological differences between the recently described subgroup (BVDV-1l) and BVDV-1a/-1b, which are widely used in commercial vaccines. Considering the cross neutralization titers, it is concluded that selected BVDV-1l and BVDV-1h strains can be used for the development of diagnostic and control tools.eninfo:eu-repo/semantics/closedAccessBovine viral diarrhea virusBVDV-1Cross neutralizationSerological relationSubgroupMicrobiologyVeterinary SciencesAntigenic diversityFetal protectionInfectionIdentificationHeterogeneitySubgenotypesVaccinationExposureFailureDiseaseAnimalsAntibodies, neutralizingAntibodies, viralAntigens, viralBovine virus diarrhea-mucosal diseaseCattleCell lineDiarrheaDiarrhea virus 1, bovine viralGenotypeSheepSpecies specificityArticle0003480831000012-s2.0-8491621471816175125487441MicrobiologyVeterinary sciencesBovine Viral Diarrhea Viruses; Pestivirus; CattleAntiserumNeutralizing antibodyVirus antibodyVirus antigenAnimal experimentAntibody titerArticleBlood samplingBovine viral diarrhea virus 1Bovine viral diarrhea virus 1aBovine viral diarrhea virus 1bBovine viral diarrhea virus 1dBovine viral diarrhea virus 1fBovine viral diarrhea virus 1hBovine viral diarrhea virus 1lControlled studyExperimental sheepGenotypeImmunizationNonhumanSerologyVirus neutralizationVirus strainAnimalBloodBovineBovine viral diarrheaBovine viral diarrhea virus 1Cell lineDiarrheaGeneticsImmunologySheepSpecies differenceVirology