Atuğ, ÖzlenYılmaz, Yusuf2021-11-152021-11-152009-06Yılmaz, Y. vd. (2009). "Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease". Clinical Biochemistry, 42(9), 802-807.0009-9120https://doi.org/10.1016/j.clinbiochem.2009.02.003https://www.sciencedirect.com/science/article/pii/S0009912009000848http://hdl.handle.net/11452/22650Objectives: Levels of soluble receptor for advanced glycation endproducts (sRAGE) have been linked to several components of the metabolic syndrome. We tested the hypothesis that plasma levels of sRAGE may be associated with non-alcoholic fatty liver disease. Design and methods: We enrolled subjects with definite nonalcoholic steatohepatitis (NASH, n=40), borderline NASH (n=8), simple fatty liver (n=9) and healthy controls (n=14). Plasma levels of sRAGE were measured by ELISA. Results: Concentrations of sRAGE were significantly lower in patients with definite NASH (1080 +/- 392 pg/mL, P<0.01) and borderline NASH (1050 +/- 278 pg/mL, P<0.05) compared to controls (1480 +/- 387 pg/mL). Levels of sRAGE were significantly and inversely correlated with ALT (r=-0.30, P<0.05) and AST (r=-0.23, P<0.05). Conclusion: Plasma levels of sRAGE are significantly reduced in definite and borderline NASH.eninfo:eu-repo/semantics/closedAccessFatty liverBiological markersReceptor for advanced glycation endproducts (RAGE)Enzyme-linked immunosorbent assayEnd-products agesInsulin-resistanceSerum-levelsRageFormPathogenesisGalectin-3ProteinMedical laboratory technologyAdultEnzyme-linked immunosorbent assayFatty liverHumansMiddle agedReceptors, immunologicArticle0002662959000082-s2.0-6734926346780280742919217891Medical laboratory technologyAdvanced Glycation End Product Receptor; 6 N Carboxymethyllysine; GlycationAdvanced glycation end product receptorAlanine aminotransferaseAdultAlanine aminotransferase blood levelControlled studyArticleDisease associationEnzyme linked immunosorbent assayFatty liverFemaleHumanHuman tissueInsulin resistanceLiver biopsyMajor clinical studyMaleNonalcoholic fatty liverPriority journalProtein blood level