Wang, LeiMaher, Timothy JohnWurtman, Richard2021-11-092021-11-092008-11Cansev, M. vd. (208). ''Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease''. Neuroscience Research, 62(3), 206-209.0168-01021872-8111https://doi.org/10.1016/j.neures.2008.07.005https://www.sciencedirect.com/science/article/pii/S0168010208002174http://hdl.handle.net/11452/22592Administering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 clays after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may Partially restore dopaminergic neurotransmission in this model of Parkinson's disease.eninfo:eu-repo/semantics/openAccessParkinson's diseaseUridineDocosahexaenoic acidDopamineTyrosine hydroxylase activitySynapseNeurite outgrowthPartial lesionsFatty-acidsBrainDopamineSupplementationReleaseGerbilsOmega-3SystemNeurosciences & neurologyAnimalsCentral nervous system stimulantsCorpus striatumDextroamphetamineDocosahexaenoic acidsDopamineFunctional lateralityInjectionsMaleNeostriatumOxidopamineParkinson diseaseSecondaryRatsRats, sprague-dawley;Stereotyped behaviorSympatholyticsTyrosine 3-monooxygenaseUridineArticle0002609296000082-s2.0-5294913186620620962318761383NeurosciencesDocosahexaenoic Acids; Omega 3 Fatty Acid; Fish OilsDexamphetamineDocosahexaenoic acidDopamineOxidopaminePhospholipidSynapsin ITyrosine 3 monooxygenaseUridine phosphateAnimal experimentAnimal modelArticleCircling behaviorControlled studyCorpus striatumDopamine metabolismDopamine releaseDopaminergic transmissionDrug effectEnzyme activityMaleNonhumanParkinson diseaseNeurotransmissionPriority journalRatSynaptic membrane