2021-11-292021-11-292008-03Yılmaz, Z. vd. (2008). ''Endotoxin increases plasma leptin and ghrelin levels in dogs''. Critical Care Medicine, 36(3), 828-833.0090-34931530-0293https://doi.org/10.1097/01.CCM.0B013E3181611F5AAhttps://journals.lww.com/ccmjournal/Fulltext/2008/03000/Endotoxin_increases_plasma_leptin_and_ghrelin.24.aspxhttp://hdl.handle.net/11452/22848Objective. Evaluations of plasma leptin and ghrelin levels and their relations with circulating levels of proinflammatory mediators, stress hormones, and biochemical markers of hepatorenal injury during experimental endotoxemia in dogs. Setting: Uludag University. Design: Placebo-controlled animal study. Animals, Adult mongrel dogs (n = 16). Interventions. Intravenous injection of endotoxin (1 mg/kg) and blood sample withdrawal before and at 0.5-48 hrs posttreatment. Measurements and Main Results. Mean baseline plasma leptin and ghrelin levels were 2.4 +/- 0.1 ng/mL and 867 +/- 58 pg/mL, respectively. Plasma leptin and ghrelin increased significantly by 16% (p <.05) and 72% (p <.001) at 0.5 hr, and they remained elevated by 33-41 % (p <.001) and 59-74% (p <.001) at 48 hrs after administration of endotoxin, respectively. There was positive correlation (r =.844; p <.001) between plasma leptin and ghrelin levels in endotoxin-treated dogs. Endotoxemia was associated with several-fold elevations in circulating levels of stress hormones, proinflammatory mediators, and hepatorenal injury markers. Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r =.955 and r =.890; p <.001), procalcitonin (r =.825 and r =.716; p <.001), cortisol (r =.823 and r =.786; p <.001), and hepatorenal injury markers (r =.580 to.745 and r =.393 to.574; p <.05 to.01). Conclusions. Circulating leptin and. ghrelin levels increase during endotoxemia, and these increases are associated with elevated levels of proinflarnmatory mediators, stress hormones, and serum biochemical markers for hepatorenal dysfunction.eninfo:eu-repo/semantics/closedAccessLeptinGhrelinNitric oxideProcalcitoninEndotoxinLipopolysaccharideDogPlatelet closure timesCirculating leptinSerum leptinLipopolysaccharideSepsisActivationExpressionCytokinesResponsesInfusionGeneral & internal medicineAnimalsDogsEndotoxemiaFemaleGhrelinLeptinMaleArticle0002534505000232-s2.0-4444913434282883336318431270Critical care medicineGhrelin Receptors; Acyltransferases; Growth Hormone Releasing HexapeptideEndotoxinGhrelinHydrocortisoneLeptinNitric oxideProcalcitoninStress hormoneGhrelinLeptinAnimal experimentAnimal modelArticleControlled studyDisease courseDisease markerEndotoxemiaFemaleHormone blood levelHormone responseKidney injuryLiver injuryMaleNonhumanPriority journalAnimalBloodDog