Özbek, UǧurSırma, SemaAğaoğlu, LeylaYüksel, LebrizAnak, SemaYıldız, İnciDevecioğlu, OmerTimur, ÇetinGedikoğlu, Gündüz2023-03-242023-03-242003-03Özbek, U. vd. (2003). “Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey”. Journal of Pediatric Hematology Oncology, 25(3), 204-208.1077-4114https://doi.org/10.1097/00043426-200303000-00005https://journals.lww.com/jpho-online/fulltext/2003/03000/prognostic_significance_of_the_tel_aml1_fusion.5.aspxhttp://hdl.handle.net/11452/31731Purpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey. Methods: The authors analyzed 219 children with ALL using the reverse transcription-polymerase chain reaction. Results: The TEL-AML1 fusion transcript was detected in 20.1% (44/219) of newly diagnosed children with ALL. TEL-AML1-positive patients had precursor B-cell ALL and were 3 to 10 years old at diagnosis. TEL-AML1-positive patients had a significantly lower rate of relapse compared with TEL-AML1-negative patients. TEL-AML1-positive patients have a higher overall survival rate than TEL-AML1-negative patients. Conclusions: These data support that the presence of TEL-AML1 at diagnosis is an independent favorable prognostic indicator in patients with ALL in Turkey.eninfo:eu-repo/semantics/closedAccessOncologyHematologyPediatricsAcute lymphoblastic leukemiaPediatric leukemiaTEL-AML1TEL/AML1 fusionCryptic t(12-21)ChildhoodChildrenTranscriptFrequencySubgroupRelapseAdolescentChildChild, preschoolCore binding factor alpha 2 subunitFemaleHumansImmunophenotypingInfantInfant, newbornLeukemia, lymphocytic, acuteMaleOncogene proteins, fusionPrognosisSurvival rateTurkeyArticle0001814168000032-s2.0-003733614220420825312621238OncologyHematologyPediatricsAcute Lymphoblastic Leukemia; Chromosome 21; Pre B LymphocyteAcute lymphoblastic leukemiaArticleCancer incidenceChildChildhood leukemiaClinical featureFemaleFusion geneHumanImmunophenotypingKaplan meier methodMajor clinical studyMalePre b lymphocytePriority journalPrognosisReciprocal chromosome translocationRelapseReverse transcription polymerase chain reactionSurvival rateTurkey (republic)Hybrid proteinTel aml1 proteinUnclassified drug