İnanç, MuratDireskeneli, HanerKamalı, SevilKasapoğlu, Günal EsenElbir, Yeşim2022-08-172022-08-172007İnanç, N. vd. (2007). "Anti-CCP antibodies in rheumatoid arthritis and psoriatic arthritis". Clinical Rheumatology, 26(1), 17-23.0770-31981434-9949https://doi.org/10.1007/s10067-006-0214-5https://link.springer.com/article/10.1007%2Fs10067-006-0214-5http://hdl.handle.net/11452/28216Our aim is to assess the prevalence and associated clinical features of anti-CCP (cyclic citrullinated peptide) antibodies for RF (rheumatoid factor)-positive and RF-negative rheumatoid arthritis (RA) and psoriatic arthritis (PsA). In a prospective, cross-sectional, multi-centre study, we determined the titres of anti-CCP antibodies in 208 RA patients (129 RF-positive, 79 RF-negative), 56 PsA patients and 39 healthy controls (HC). Clinical parameters including disease activity (disease activity score 28-DAS28), physical disability (health assessment questionnaire-HAQ), functional capacity (functional class) and radiological erosions were investigated in patients with RA. In PsA patients, clinical and radiological features were determined. Anti-CCP2 antibodies were measured using a second-generation anti-CCP enzyme-linked immunosorbent assay (Euro-Diagnostica, Netherlands). One-hundred four of 129 RF-positive RA (81%), 16 of 79 RF-negative RA (20%), seven of 56 PsA patients (12.5%) and none of the HC had anti-CCP antibodies. RA patients with anti-CCP antibodies had significantly higher disease activity, greater loss of function and more frequent erosive disease than anti-CCP antibody-negative group. In subgroup analysis, anti-CCP antibodies in RF-negative patients were also associated with erosive disease. All PsA patients with anti-CCP antibodies had symmetric arthritis with higher number of swollen joints. The prevalence of anti-CCP antibodies in RF-positive RA patients was significantly higher than in RF-negative RA and PsA patients. Anti-CCP antibodies were also associated with erosive disease in RF-negative RA patients. Both anti-CCP and RF tests were negative in 30% of the patients. Anti-CCP positivity was a frequent finding in PsA and associated with symmetrical polyarthritis.eninfo:eu-repo/semantics/closedAccessAnti-CCP antibodiesPsoriatic arthritisRheumatoid arthritisRheumatoid factorCitrullinated peptide antibodiesAntikeratin antibodiesPrognostic valueDiagnostic-valueAutoantibodiesProgressionAssociationsDiseaseClassificatıonCriteriaAutoantibodiesAdultAgedAged, 80 and overArthritis, psoriaticArthritis, rheumatoidNetherlandsCase-control studiesCross-sectional studiesEnzyme-linked immunosorbent assayPeptides, cyclicProspective studiesSensitivity and specificityFemaleHumansMaleMiddle agedArticle0002430321000052-s2.0-33845906856172326116538391RheumatologyCyclic Citrullinated Peptide Antibody; Rheumatoid Factor; CitrullinationDisease severityAdultAgedArticleBone erosionBone radiographyClinical featureClinical trialControlled clinical trialControlled studyDisease activityDisease markerFemaleDrug megadoseEnzyme linked immunosorbent assayErythrocyte sedimentation rateLow drug doseFunctional statusHumanJoint swellingMaleMethotrexateMajor clinical studyPhysical disabilityCytokine receptor antagonistDisease modifying antirheumatic drugMulticenter studySpondylarthritisCyclic citrullinated peptide antibodyPolyarthritisPrevalencePriority journalPrognosisPsoriatic arthritisRheumatoid arthritisScoring systemTumor necrosis factor antagonistCorticosteroidSubcutaneous noduleTendinitisRheumatoid factorUnclassified drug