2022-01-242022-01-242009-10-09İşbil, N. B. vd. (2009). "Effect of peripherally-injected glucagon-like peptide-1 on gastric mucosal blood flow". Regulatory Peptides, 157(1-3), 72-75.0167-0115https://doi.org/10.1016/j.regpep.2009.04.013https://www.sciencedirect.com/science/article/pii/S0167011509000913http://hdl.handle.net/11452/24263The aim of this study was to investigate the mechanisms involved in the effect of glucagon-like peptide-1 (GLP-1) on the decrease in gastric mucosal blood flow (GMBF) induced by intragastric ethanol. After preparation of the stomach for GMBF recording, a probe was placed to the gastric mucosa and basal GMBF recordings were obtained by a laser Doppler flowmeter after a 30-minute stabilization period. Following GLP-1 (1000 ng/kg; i.p.) injection, 1 ml of absolute ethanol was applied to the gastric chamber and GMBF was recorded continuously during a 30-minute period. GLP-1 (1000 ng/kg; i.p.) prevented the decrease in GMBF induced by ethanol. Nitric oxide (NO) synthase inhibitor L-NAME, (30 mg/kg; s.c.), calcitonine gene-related peptide (CGRP) receptor antagonist CGRP-(8-37) (10 mu g/kg; i.p.), and cyclooxygenase inhibitor indomethacin (5 mg/kg; i.p.) all inhibited the GMBF-improving effect of GLP-1. We concluded that, NO, CGRP and prostaglandins may be involved in the effect of peripherally-injected GLP-1 on GMBF reduction induced by intraluminal ethanol.eninfo:eu-repo/semantics/closedAccessCGRP-(8-37)EthanolGastric mucosal blood flowGLP-1IndomethacinL-NAMEGene-related peptideExperimental-modelsGlp-1EthanolRatSystemAmideSomatostatinInvolvementMechanismsEndocrinology & metabolismPhysiologyAnimalsCalcitonin gene-related peptideEthanolGastric mucosaGlucagon-like peptide 1Injections, intraperitonealMaleNitric oxideNitric oxide synthasePeptide fragmentsRatsRats, sprague-dawleyRegional blood flowTime factorsArticle0002697406000132-s2.0-6834909278572751571-319427335Endocrinology & metabolismPhysiologyGastric Mucosa; Stomach; Vanilloid Receptor 1AlcoholCalcitonin gene related peptideCalcitonin gene related peptide[8-37]Glucagon like peptide 1IndometacinN(g) nitroarginine methyl esterNitric oxideProstaglandin derivativeAnimal experimentArticleControlled studyDrug effectDrug mechanismLaser Doppler flowmetryMaleNonhumanOutcome assessmentPriority journalRatStomach mucosa blood flowStomach protection