2022-11-182022-11-182013-05Duşak, A. vd. (2013). "Correlation between hippocampal volume and excessive daytime sleepiness in obstructive sleep apnea syndrome". European Review for Medical and Pharmacological Sciences, 17(9), 1198-1204.1128-3602https://www.europeanreview.org/wp/wp-content/uploads/1198-1204.pdfhttp://hdl.handle.net/11452/29481BACKGROUND/AIM: The limbic system, specifically the hippocampus, plays a key role in controlling the sleep-wake cycle. Changes in these particular structures of the central nervous system have been suggested to be related to obstructive sleep apnea syndrome (OSAS). We hypothesized that reduced hippocampal volume is a risk factor for excessive daytime sleepiness (EDS) in OSAS. PATIENTS AND METHODS: Twenty-two patients with newly diagnosed OSAS and 20 healthy controls were included in the present study. Polysomnography was performed for each participant to determine the presence of OSAS. EDS was defined based on the Epworth sleepiness scale (ESS) score, and patients were grouped as sleepy or non-sleepy according to this score. The hippocampal volume was calculated by MR volumetry using a manual tracing technique. RESULTS: There was no significant difference between groups in demographic variables. The hippocampus was markedly smaller in the OSAS groups than in controls (p < 0.001 Hippocampal volume was negatively correlated with the ESS score (r = - 0.631, p = 0.002). CONCLUSIONS: Our findings suggest that EDS is associated with reduced hippocampal volume in OSAS.eninfo:eu-repo/semantics/openAccessPharmacology & pharmacyObstructive sleep apnea syndromeExcessive day-time sleepinessEpworth sleepiness scaleHippocampusMR volumetryCentral hypoventilation syndromeBrain structural-changesHypopnea syndromeMammillary bodyHypoxiaMorphologyDisordersSeverityActivationDeficitsAdultCohort studiesDisorders of excessive somnolenceFemaleHippocampusHumansImage processing, computer-assistedMagnetic resonance imagingMaleMiddle agedPolysomnographySleep apnea syndromesArticle0003195183000092-s2.0-848785790541198120417923690189Pharmacology & pharmacyObstructive Sleep Apnea; Cognitive Dysfunction; CognitionAdultArticleBrain sizeClinical articleControlled studyDaytime somnolenceElectrocardiogramElectroencephalogramElectromyogramElectrooculogramEpworth sleepiness scaleFemaleHippocampusHumanMaleNeuroimagingNuclear magnetic resonance imagingNuclear magnetic resonance scannerOxygen desaturationOxygen saturationPolysomnographyRisk factorSleep disordered breathingVolumetry