2021-12-302021-12-302010Kılıç, S. Ş. vd. (2010). "Transfusion-associated graft-versus-host disease in severe combined immunodeciency". Journal of Investigational Allergology and Clinical Immunology, 20(2), 153-156.1018-9068http://hdl.handle.net/11452/23771Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare complication of cellular blood component transfusion that produces a graft-versus-host clinical picture with concomitant bone marrow aplasia. We report the case of 2 patients with severe combined immunodeficiency (SCID) who developed TA-GvHD. Both patients had been given nonirradiated erythrocyte suspension before the diagnosis of SCID. Although one of them was aged 12 months, he had still not been diagnosed as having severe T-cell deficiency at the time of transfusion. Both patients presented similar signs and symptoms (fever, skin rash, diarrhea, pancytopenia, and icterus). Skin biopsies demonstrated Grade II GVHD involvement. In both cases, sepsis and septic shock developed, with progression to multiorgan failure. Unfortunately, the 2 patients died, despite prompt, appropriate sepsis treatment and immunomodulatory therapy. TA-GVHD must be considered in the differential diagnosis of patients who present fever, pancytopenia, diarrhea, skin rash and icterus, and the transfusion history must be questioned.eninfo:eu-repo/semantics/closedAccessTransfusion-associated graft-versus-host diseaseSevere combined immunodeficiencyIrradiationSkin biopsyFatal graftDeficiencyBloodAllergyImmunologyEarly diagnosisErythrocyte transfusionExanthemaFatal outcomeGraft vs host diseaseHumansInfantMaleMultiple organ failureRecurrenceRespiratory tract infectionsSevere combined immunodeficiencyShock, septicSkinArticle0002772479000082-s2.0-7795363098215315620220461970AllergyImmunologyTransfusion; Graft Vs Host Disease; Blood BanksAminotransferaseAmphotericin BAntibiotic agentCefepimeCyclosporinFluconazoleFresh frozen plasmaGamma glutamyltransferaseGanciclovirGranulocyte colony stimulating factorImmunoglobulinMeropenemMethylprednisoloneTeicoplaninThymocyte antibodyAminotransferase blood levelArticleBacterium cultureCase reportCell suspensionChildDeathDiarrheaDrug megadoseErythrocyte concentrateErythrocyte transfusionFebrile neutropeniaFeverHumanHuman cellHuman tissueImmunoglobulin deficiencyInfantInfectionJaundiceKlebsiella pneumoniae infectionLaboratory testMaleMucosa inflammationMultiple organ failureMycosisPancytopeniaPreschool childRashRespiratory tract infectionSepsisSeptic shockSevere combined immunodeficiencySkin biopsyTransfusion associated graft versus host diseaseVirus infectionEarly diagnosisErythrocyte transfusionFatalityGraft versus host reactionImmunologyPathologyPathophysiologyRecurrent diseaseRespiratory tract infectionSevere combined immunodeficiencySkin