Aydın, ÖmerBüyükkaya, Ramazan2023-01-302023-01-302017-01-01Aydın, Ö. vd. (2017). ''Contrast medium enhanced susceptibility imaging signal mechanism; should we use contrast medium?''. Acta Radiologica, 58(1), 107-113.0284-1851https://doi.org/10.1177/02841851166372461600-0455https://journals.sagepub.com/doi/10.1177/0284185116637246http://hdl.handle.net/11452/30713Background Intracranial lesions exhibit clear contrast enhancement in T1-weighted imaging, but the mechanism whereby contrast-enhanced susceptibility-weighted imaging (CE-SWI) generates signals remains unclear. Contrast enhancement patterns cannot be reliably predicted. Purpose To explore the mechanism of CE-SWI contrast enhancement. Material and Methods Fifty-five patients were retrospectively enrolled. All of the imaging employed a clinical 3T magnetic resonance imaging (MRI) system fitted with a 32-channel head coil. Minimum-intensity projection reformatted images were evaluated. Intracranial lesions and brain parenchymal intensities were explored using SWI and CE-SWI. signal intensity rates were calculated by dividing the lesional intensity by the white matter intensity, after which the SWI and CE-SWI signal intensity rate were compared. Two observers independently performed intralesional susceptibility signal analysis. Results After contrast medium administration, malignant and extra-axial tumors exhibited obvious contrast enhancement on CE-SWI (P<0.001 and P=0.013, respectively). The signal intensity of white matter was significantly reduced. The signal intensity rates rose significantly in the benign, malignant, and extra-axial groups (P<0.001). Between-radiologist agreement in terms of intralesional susceptibility signal assessment was strong (kappa=0.8, P<0.001). Conclusion Contrast media can either reduce or increase SWI signal intensities. The dual contrast feature of CE-SWI can be useful when exploring intracranial disorders.eninfo:eu-repo/semantics/closedAccessRadiology, nuclear medicine & medical imagingContrast mediumSusceptibility weighted imagingBlood brain barrierAngiogenesisTumorHigh-resolutionRadiation necrosisGrade gliomasBrainDifferentiationPatternsMagnetic resonance imagingTissueTumorsAngiogenesisBlood-brain barrierContrast enhancementContrast mediumContrast-enhancedSignal intensitiesSusceptibility weighted ImagingWhite matterContrast mediaAdolescentAdultAgedBrain neoplasmsChildChild, preschoolContrast mediaFemaleHumansImage enhancementImage interpretation, computer-assistedMagnetic resonance angiographyMaleMeglumineMiddle agedNeovascularization, pathologicOrganometallic compoundsReproducibility of resultsSensitivity and specificityYoung adultArticle0003905579000152-s2.0-8500648374210711358126966145Radiology, nuclear medicine & medical imagingSubstantia Nigra; Susceptibility; PulvinarGadoterate meglumineContrast mediumGadoterate meglumineMeglumineOrganometallic compoundAdolescentAgedArticleBenign neoplasmBrain cancerBrain damageBrain tissueChildContrast enhancementControlled studyFemaleHumanImage analysisImage displayImage processingIntermethod comparisonInterrater reliabilityIntracranial tumorMajor clinical studyMaleNuclear magnetic resonance scannerParenchymaPriority journalRetrospective studySignal detectionSusceptibility weighted imagingWhite matterAdultBrain tumorComplicationComputer assisted diagnosisDiagnostic imagingImage enhancementMagnetic resonance angiographyMiddle agedNeovascularization (pathology)Preschool childProceduresReproducibilitySensitivity and specificityYoung adult