Öncan, TevfikErmutlu, Cenk2024-03-252024-03-252013Öncan, T. vd. (2013). “Effect of low-dose irradiation on structural and mechanical properties of hyaline cartilage-like fibrocartilage”. Acta Orthopaedica et Traumatologica Turcica, 47(2), 127-133.1017-995Xhttps://www.aott.org.tr/en/effect-of-lowdose-irradiation-on-structural-and-mechanical-properties-of-hyaline-cartilagelike-fibrocartilage-134136https://hdl.handle.net/11452/40605Objective: The aim of this study was to analyze the effect of low-dose irradiation on fibrous cartilage and to obtain a hyaline cartilage-like fibrocartilage (HCLF) with similar structural and mechanical properties to hyaline cartilage.Methods: An osteochondral defect was created in 40 knees of 20 rabbits. At the 7th postoperative day, a single knee of each rabbit was irradiated with a total dose of 5.0 Gy in 1.0 Gy fractions for 5 days (radiotherapy group), while the other knee was not irradiated (control group). Rabbits were then divided into four groups of 5 rabbits each. The first three groups were sacrificed at the 4th, 8th and the 12th postoperative weeks and cartilage defects were macroscopically and microscopically evaluated. The remaining group of 5 rabbits was sacrificed at the 12th week and biomechanical compression tests were performed on the cartilage defects.Results: There was no significant biomechanical difference between the radiotherapy and the control group (p=0.686). There was no significant macroscopic and microscopic difference between groups (p=0.300). Chondrocyte clustering was observed in the irradiated group.Conclusion: Low-dose irradiation does not affect the mechanical properties of HCLF in vivo. However, structural changes such as chondrocyte clustering were observed.eninfo:eu-repo/semantics/openAccessOrthopedicsHyaline cartilageHyaline cartilage-like fibrocartilageLow-dose irradiationMechanicalStructuralFull-thickness defectsAdjuvant-induced arthritisAutogenous periosteal graftsContinuous passive motionRabbit knee-jointArticular-cartilageRadiation-therapyOsteochondral defectsBenign diseasesRepairAnimalsBiomechanicsCartilage, articularCell differentiationFemaleFibrocartilageKnee jointRabbitsRadiation dosageArticle0003192321000112-s2.0-8488060457712713347223619547https://doi.org/10.3944/AOTT.2013.2709OrthopedicsArticular Cartilage; Chondrocytes; CartilageAnimalArticleArticular cartilageBiomechanicsCell differentiationCytologyFemaleFibrocartilageKneePathologyPhysiologyRabbitRadiation doseRadiation exposure