Şimşek, AbdurrahmanKızmaz, Muhammed A.Çağan, ErenDombaz, FatmaTezcan, GülçinAsan, AliDemir, H. İbrahimBal, S. HaldunErmiş, Diğdem Y.Dilektaşlı, Aslı G.Kazak, EsraAkalın, E. HalisOral, H. BarbarosBudak, Ferah2024-11-112024-11-112022-01-260146-6615https://doi.org/10.1002/jmv.27593https://onlinelibrary.wiley.com/doi/10.1002/jmv.27593https://hdl.handle.net/11452/47686COVID-19 is a disease characterized by acute respiratory failure and is a major health problem worldwide. Here, we aimed to investigate the role of CD39 expression in Treg cell subsets in COVID-19 immunopathogenesis and its relationship to disease severity. One hundred and ninety COVID-19 patients (juveniles, adults) and 43 volunteers as healthy controls were enrolled in our study. Flow cytometric analysis was performed using a 10-color monoclonal antibody panel from peripheral blood samples. In adult patients, CD39(+) Tregs increased with disease severity. In contrast, CD39(+) Tregs were decreased in juvenile patients in an age-dependent manner. Overall, our study reveals an interesting profile of CD39-expressing Tregs in adult and juvenile cases of COVID-19. Our results provide a better understanding of the possible role of Tregs in the mechanism of immune response in COVID-19 cases.eninfo:eu-repo/semantics/openAccessCd39Covid-19Foxp3Infectious diseasesTregsVirologyArticle0007469005000012089210194510.1002/jmv.27593