Aydın, Mehmet FethullahYıldız, AbdülmecitOruç, AyşegülVuruşkan, Berna AytaçAkgür, SuatAyar, YavuzGüllülü, MustafaDilek, KamilYavuz, MahmutOrtaç, HaticeErsoy, Alparslan2024-11-082024-11-082022-09-250301-1623https://doi.org/10.1007/s11255-022-03371-6https://link.springer.com/article/10.1007/s11255-022-03371-6https://hdl.handle.net/11452/47611Background The histopathological classification of ANCA-GN divides patients into four groups based on signs of glomerular injury. However, this classification did not consider age-related glomerulosclerosis. In this study, we aimed to compare the prediction of renal survival between Berden's ANCA-GN histopathological classification and ANCA-GN histopathological classification modified with age-related glomerulosclerosis. Methods Between January 2004 and December 2019, 65 patients diagnosed with ANCA-GN were enrolled. Demographic, laboratory, and histopathologic findings were retrospectively analyzed. Renal survival analyses were compared according to classical and modified ANCA-GN histopathological classifications. Multivariate Cox regression analysis for the factors affecting renal survival was performed. Results In Berden's ANCA-GN histopathological classification, 15 patients were in the focal group, 21 in the crescentic, 21 in the sclerotic, and 8 in the mixed group. The ANCA-GN histopathological classification model generated statistically significant predictions for renal survival (p = 0.022). When the histopathological classification was modified with age-related glomerulosclerosis, eight of the nine patients previously classified in the sclerotic group were classified in the mixed and one in the crescentic groups. Modification of histopathological classification with age-related glomerulosclerosis increases the statistical significance in renal survival analysis (p = 0.009). The multivariate Cox regression analysis showed that the disease-related global sclerotic glomeruli percentage and serum creatinine level were significant independent factors. Conclusion Modification of Berden's ANCA-GN histopathological classification model with age-related glomerulosclerosis may increase the statistical significance of the histopathological classification model.eninfo:eu-repo/semantics/openAccessAntibody-associated glomerulonephritisHistological classificationNephrosclerosisValidationDiseaseBiopsyAncaAnca-associated vasculitisAnti-neutrophil cytoplasmic antibodiesAge-related glomerulosclerosisHistopathological classificationRenal pathologyUrology & nephrologyArticle00085880000000274174855310.1007/s11255-022-03371-6