Avcı, Okanİriagaç, YakupCavdar, EyyüpKaraboyun, KubilayAraz, MuratSakalar, TeomanDegerli, EzgiÖzdemir, ÖzlemInal, AliÜrün, MuslihSakin, AbdullahTacar, Seher YıldızKoçak, Mehmet ZahidDemir, HacerÖzer, ÖzdenSimşek, Eda TanrıkuluErsoy, MustafaKarakas, YusufArıkan, RukiyeEsbah, OnurOn, SercanTasçı, Elif ŞenocakMandel, Nil MolinasTürker, SemaKacan, TurgutYıldırım, Hasan CağrıAlan, ÖzkanAkbaş, SinemDeniz, Gülhan İpekIsak, Özlem AydınTaşkaynatan, HalilSeber, Erdoğan Selçuk2024-12-042024-12-042023-09-061879-4068https://doi.org/10.1016/j.jgo.2023.101604https://hdl.handle.net/11452/48885Introduction: In this study, the toxicities and management of palbociclib and ribociclib in older patients (>= 65 years) with metastatic breast cancer patients were investigated.Materials and Methods: Among older patients receiving palbociclib and ribociclib, Geriatric 8 (G8) and Groningen Frailty Index were used to evaluate frailty status. Dose modifications, drug withdrawal and other serious adverse events (SAEs) were recorded and analyzed according to baseline patient characteristics.Results: A total of 160 patients from 28 centers in Turkey were included (palbociclib = 76, ribociclib = 84). Forty-three patients were >= 75 years of age. The most common cause of first dose modification was neutropenia for both drugs (97% palbociclib, 69% ribociclib). Liver function tests elevation (10%) and renal function impairment (6%) were also causes for ribociclib dose modification. Drug withdrawal rate was 3.9% for palbociclib and 6% for ribociclib. SAEs were seen in 11.8% of those taking palbociclib and 15.5% of those on riboclib. An ECOG performance status of >= 2 and being older than 75 years were associated with dose reductions. Severe neutropenia was more common in patients with non-bone-only metastatic disease, those receiving treatment third-line therapy or higher, coexistance of non-neutropenic hematological side effects (for ribociclib). Neutropenia was less common among patients with obesity.Discussion: Our results show that it can be reasonable to start palbociclib and ribociclib at reduced dose in patients aged >= 75 years and/or with an ECOG performance status >= 2.eninfo:eu-repo/semantics/closedAccessGroningen frailty indicatorGeriatric assessmentEndocrine therapyLetrozoleToolsG8GeriatricsCdk 4/6 inhibitorsBreast cancerAdverse eventsScience & technologyLife sciences & biomedicineOncologyGeriatrics & gerontologyArticle00107848620000114810.1016/j.jgo.2023.101604