Changes in left ventricular blood flow during diastole due to differences in chamber size in healthy dogs

Matsuura, KatsuhiroSato, KotomiShimada, KazumiGoya, SeijirowUemura, AkikoIso, TakeshiYazaki, KanaTakahashi, KenTanaka, Ryou2024-02-052024-02-052020-01-24Matsuura, K. vd. (2020). "Changes in left ventricular blood flow during diastole due to differences in chamber size in healthy dogs". Scientific Reports, 10(1).2045-2322https://www.nature.com/articles/s41598-019-57180-6https://hdl.handle.net/11452/39507Vorticity is a novel index that reflects diastolic function of left ventricle. The size of the ventricle can influence the ventricular diastolic blood flow. We evaluated effect of ventricular size on diastolic function and diastolic intracardiac blood flow using a particular species of dogs, which has a wide range of body size. Vector flow mapping was used for evaluation of intracardiac blood flow, and intraventricular pressure gradient (IVPG) was used for evaluation of diastolic function. 58 dogs weighing 1.3-42.3 kg were included in this study. Vorticity was found to be inversely proportional to the length of the ventricular chamber. Intraventricular pressure difference was positively correlated with the length of the left ventricle, whereas IVPG was not. This study showed that the vorticity is influenced by the size of the left ventricle independently of other factors. To evaluate the hemodynamic state of each individual appropriately by using vorticity and IVPD, ventricular size should be taken into account especially in the field of veterinary medicine and human pediatric and adolescent cardiology.eninfo:eu-repo/semantics/openAccessScience & technology - other topicsIntraventricular pressure-gradientsDysfunctionAnimalsBlood flow velocityBody constitutionDiastoleDogsHeart ventriclesOrgan sizeVentricular functionChanges in left ventricular blood flow during diastole due to differences in chamber size in healthy dogsArticle0005628465000022-s2.0-8507824887710131980646https://doi.org/10.1038/s41598-019-57180-6Multidisciplinary sciencesHeart Left Ventricle; Mitral Valve; HemodynamicAdolescentAnimal experimentArticleBody sizeCardiologyControlled studyDiastoleDogFemaleHeart left ventricleHeart muscle blood flowHeart ventricle pressureMaleNonhumanVeterinary medicineAnatomy and histologyAnimalBlood flow velocityBody constitutionDiastoleHeart ventricleHeart ventricle functionOrgan sizePhysiology