2021-12-162021-12-161997Kahveci, N. vd. (1997). "The effects of drugs on intracranial pressure, cerebral perfusion pressure and histopathological investigation of the infarct areas in focal cerebral ischemia model in rats". ed. Monduzzi Editore. 11th International Congress of Neurological Surgery, 1-2, 1851-1855.88-323-0706-5http://hdl.handle.net/11452/23300Bu çalışma, 6-11 Temmuz 1997 tarihlerinde Amsterdam[Hollanda]'da düzenlenen 11. International Congress of Neurological Surgery'de bildiri olarak sunulmuştur.The effects of neuroprotective drugs in focal cerebral ischemia induced after MCA occlusion were investigated in adults rats. Group I rats (n:10) received nimodipine (1 mg/kg/min); Group II (n:10) etomidate (75 mg/kg, iv + 0.5 mg/kg/min iv maintenance); Group III (n:10) lidocaine (5 mg/kg iv + 0.4 mg/kg/min iv maintenance); Group IV (n:12) vehicle solution. In all groups rats were observed 300 min after MCAO and MABP, ICP measurements were recorded at 30 min intervals. There was no change in MABP values in Group I and II whilst these values decreased in Group III and IV. ICP increased in all groups. 24 h after occlusion in TTC stained brain sections smaller infarct areas were observed in Group I and II comparing to Group III and IV. Histopathological examination confirmed the findings. In conclusion, nimodipine has a protective effect on ICP, CPP and infarct area whereas etomidate has limited and lidocaine no effect at all.eninfo:eu-repo/semantics/closedAccessNeurosciences & neurologyProceedings PaperA1997BJ48C00317185118551-2Clinical neurology