Kaya, HakanDesdicioğlu, RaziyeSezik, MekinÖzkaya, Okan2021-12-202021-12-202008-03Kaya, H. vd. (2008). ''Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?''. Fertility and Sterility, 89(3), 732-735.0015-02821556-5653https://doi.org/10.1016/j.fertnstert.2007.03.065https://www.sciencedirect.com/science/article/abs/pii/S0015028207007947http://hdl.handle.net/11452/23409The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.eninfo:eu-repo/semantics/closedAccessOocyte apoptosisActivationSurvivalChemotherapyFolliclesGranulosaCaspase-3AcidObstetrics & gynecologyReproductive biologyAnimalsAntineoplastic agents, alkylatingApoptosisCyclophosphamideDisease models, animalFemaleInjections, intraperitonealLysophospholipidsOvarian diseasesOvarian follicleOvulation inductionRadiation injuries, experimentalRatsRats, wistarSphingosineWhole-body irradiationEditorial Material0002540267000372-s2.0-4024911489573273589317517398Obstetrics & gynecologyReproductive biologyFertility Preservation; Ovulation Induction; VitrificationCyclophosphamideCytotoxinDrug metaboliteSphingosine 1 phosphateAnimal cellAnimal experimentAnimal modelAnimal tissueApoptosisArticleCell survivalControlled studyDrug effectFemaleNonhumanOvaryOvary diseaseOvary folliclePriority journalProtectionRatWhole body radiation