2024-03-292024-03-292008Gurbet, A. vd. (2008). ''Combination of ultra-low dose bupivacaine and fentanyl for spinal anaesthesia in out-patient anorectal surgery". Journal of International Medical Research, 36(5), 964-970.0300-06051473-2300https://doi.org/10.1177/147323000803600512https://journals.sagepub.com/doi/10.1177/147323000803600512https://hdl.handle.net/11452/40675This study investigated whether the addition of 25 mu g fentanyl to an ultra-low (sub-an aesthetic) dose of intrathecal bupivacaine provides adequate anaesthesia for out-patient anorectal surgery, without increasing side-effects or delaying hospital discharge. Patients were randomly allocated to receive 2.5 mg 0.5% bupivacaine plus 25 mu g fentanyl (group BF, n = 18) or 5 mg 0.5% bupivacaine alone (group B, n = 17). There were no significant differences in intra-operative outcomes, but mean recovery and discharge times were significantly shorter in group BF. There were no between-group differences in hypotension, bradycardia or respiratory depression and post-operative complications were comparable, apart from pruritus which was significantly more frequent in group BF. Fewer patients requested analgesic medication in the early post-operative period in group BF than in group B. In conclusion, 25 mu g intrathecal fentanyl added to ultra-low dose (2.5 mg) bupivacaine provided good-quality spinal anaesthesia and reduced post-operative analgesic requirement in patients undergoing ambulatory anorectal surgery.eninfo:eu-repo/semantics/openAccessAnorectal surgeryBupivacaineFentanylIntrathecalUltra-low doseIntrathecal fentanylSubarachnoid fentanylProlonging recoveryCesarean deliveryLidocaineMorphineBlockResearch & experimental medicinePharmacology & pharmacyAdultAmbulatory surgical proceduresAnal canalAnesthesia, spinalAnesthetics, localBupivacaineDouble-blind methodFemaleFentanylHumansMaleMiddle agedPain measurementPain, postoperativeProspective studiesRectumTreatment outcomeArticle0002600850000122-s2.0-5444910049696497036518831889Medicine, research & experimentalPharmacology & pharmacyChloroprocaine; Spinal Anesthesia; BupivacaineAnalgesic agentBupivacaineBupivacaineFentanylLocal anesthetic agentAdultAmbulatory surgeryAnesthetic recoveryAnorectal diseaseArticleBackacheBradycardiaClinical articleClinical trialControlled clinical trialControlled studyDouble blind procedureDrug efficacyDrug responseDrug safetyFemaleHeadacheHumanHypotensionIntraoperative periodLength of stayLow drug doseMaleMonotherapyNauseaOutcome assessmentOutpatient carePostoperative carePostoperative complicationPostoperative painPruritusRandomized controlled trialRectum surgeryRespiration depressionSpinal anesthesiaSurgical techniqueVomitingAmbulatorySurgeryAnal canalMethodologyMiddle agedPain assessmentPostoperative painProspective studyRectumTreatment outcome