Dinçer, Gülşah2021-07-022021-07-022002Sarısözen, B. vd. (2002). "The effects of vitamins E and C on fracture healing in rats". Journal of International Medical Research, 30(3), 309-313.0300-0605https://doi.org/10.1177/147323000203000312https://journals.sagepub.com/doi/10.1177/147323000203000312http://hdl.handle.net/11452/20983Forty-eight rats were divided into four groups of 12. For 3 days, each group received the following vitamins in once-daily doses: group 1, vitamin E only; group 2, vitamin C only; group 3, vitamins E and C; and group 4, no treatment (control). The right tibia of each rat was fractured on day 4; the rats then received the same regimen three times a week (once-daily doses) until day 21. Fracture healing was evaluated radiologically by measuring the callus indices, and histologically by a 5-point grading scale. On days 14 and 21, the callus index values in group 2 were statistically higher than those in the other groups. Histological evaluation scores in group 2 were the highest overall, and group 3 scores were higher than those in groups 1 and 4. These findings indicate that vitamin C accelerates fracture healing, vitamin E does not exert a marked effect on this process, and vitamins E and C in combination do not have a synergistic impact on fracture healing.eninfo:eu-repo/semantics/openAccessTocopherolAlpha-tocopherolAscorbic acidVitamin CVitamin ERatFracture healingCallus indexAscorbic-acidMc3t3-E1 cellsExpressionDifferentiationInvivoMatrixResearch & experimental medicinePharmacology & pharmacyArticle0001768119000122-s2.0-003598849230931330312166348Medicine, research & experimentalPharmacology & pharmacy