Kuşbeci, TuncayÇetinkaya, ZaferÖztürk, FarukYavaş, GülizErmiş, Sıtkı Sametİnan, Ümit Ubeyt2022-10-062022-10-062006-01-27Kuşbeci, T. vd. (2007). "The effects of caspofungin and voriconazole in experimental candida endophthalmitis". Current Eye Research, 32(1), 57-64.1460-22020271-3683https://doi.org/10.1080/02713680601107157https://www.tandfonline.com/doi/full/10.1080/02713680601107157http://hdl.handle.net/11452/28978Purpose: To evaluate the efficacy of newly developed antifungal agents caspofungin and voriconazole in Candida albicans endophthalmitis in rabbit eyes. Methods: Thirty New Zealand white rabbits were divided into four treatment groups and one control group. One eye of each rabbit was infected by inoculation of 1 x 10(4) CFU/ml of C. albicans. Seventy-two hours after the inoculation, caspofungin 100 mu g/0.1 ml in group 1 (n = 6), voriconazole 50 mu g/0.1 ml in group 2 (n = 6), amphotencin B 10 mu g/0.1 ml in group 3 (n = 6), itraconazole 10 mu g/0.1 ml in group 4 (n = 6), and 0.1 ml NaCl 0.9% in control group (n = 6) were injected into the vitreous cavity. Clinical and histopathologic examination scores and microbiological analysis of vitreous aspirates were compared. Results: There was statistically significant difference in the clinical scores, histopathologic scores, and mean CFU/ml between the treatment and control groups (p < 0.05). In caspofungin and voriconazole groups, histopathologic scores and mean CFU were lower than other treatment groups and control group. Conclusions: Intravitreal injection of caspofungin and voriconazole was effective against C. albicans endophthalmitis in this experimental rabbit model.eninfo:eu-repo/semantics/closedAccessCaspofunginAmphotericin-BEndophthalmitisExperimentalFungalVoriconazoleMycotic endophthalmitisIntravitreal injectionFluconazoleToxicityPenetrationEfficacyFungemia1stOphthalmologyPeptides, cyclicAmphotericin BAnimalsAntifungal agentsCandida albicansCandidiasisColony count, microbialCorneaDisease models, animalEndophthalmitisEye infections, fungalItraconazolePyrimidinesRabbitsTriazolesArticle0002441429000082-s2.0-33847075794576432117364736OphthalmologyEndophthalmitis; Visual Acuity; EviscerationArticleAnimal experimentAnimal modelAnimal tissueComparative studyAmphotericin B lipid complexCandida albicansCandida endophthalmitisClinical examinationColony forming unitRabbitSodium chlorideControlled studyDrug efficacyEyeFungus isolationHistopathologyMicrobiological examinationNonhumanPriority journalCaspofunginVitreous bodyScoring systemStatistical significanceAmphotericin BItraconazolePlaceboVoriconazole