Ergören, Mahmut ÇerkezÇobanoğulları, HavvaMocan, Gamze2022-12-292022-12-292020-09-18Ergören, M. Ç. vd. (2020). "Functional coding/non-coding variants in EGFR, ROS1 and ALK genes and their role in liquid biopsy as a personalized therapy". Critical Reviews in Oncology Hematology, 156.1040-84281879-0461https://doi.org/10.1016/j.critrevonc.2020.103113https://www.sciencedirect.com/science/article/pii/S1040842820302493http://hdl.handle.net/11452/30160Personalized medicine holds promise to tailor the treatment options for patients' unique genetic make-up, behavioral and environmental background. Liquid biopsy is non-invasive technique and precise diagnosis and treatment approach. Significantly, NGS technologies have revolutionized the genomic medicine by novel identifying SNPs, indel mutations in both coding and non-coding regions and also a promising technology to accelerate the early detection and finding new biomarkers for diagnosis and treatment. The number of the bioinformatics tools have been rapidly increasing with the aim of learning more about the detected mutations either they have a pathogenic role or not. EGFR, ROS1 and ALK genes are members of the RTK family. Until now, mutations within these genes have been associated with many cancers and involved in resistance formation to TKIs. This review article summarized the findings about the mostly investigated variations in EGFR, ROS1 and ALK genes and their potential role in liquid biopsy approach.eninfo:eu-repo/semantics/closedAccessEGFRROS1ALKTyrosine kinase inhibitorsLiquid biopsyPersonalized therapyCell lung-cancerPrecision medicineKinase inhibitorMutationsAssociationSensitivityTissueOncologyHematologyAnaplastic lymphoma kinaseCarcinoma, non-small-cell lungErbB receptorsHumansLiquid biopsyLung neoplasmsMutationProtein-tyrosine kinasesProto-oncogene proteinsArticle0005913356000062-s2.0-8509214373115633038629OncologyHematologyNon-Small Cell Lung Carcinoma; Anaplastic Lymphoma Kinase; CrizotinibAlectinibAnaplastic lymphoma kinaseCrizotinibEpidermal growth factor receptorErlotinibGefitinibMicroRNAOsimertinibAnaplastic lymphoma kinaseEGFR protein, humanEpidermal growth factor receptorOncoproteinProtein tyrosine kinaseROS1 protein, humanALK geneAmplification refractory mutation system polymerase chain reactionBioinformaticsBreast cancerChromosomal instabilityColorectal cancerCopy number variationEGFR geneFilter adapted fluorescent in situ hybridizationFluorescence in situ hybridizationGeneGene amplificationGene frequencyGene overexpressionGene rearrangementGene translocationGenetic variabilityGlioblastomaHead and neck cancerHigh throughput sequencingHumanImmunohistochemistryIndel mutationLiquid biopsyLung cancerNon small cell lung cancerOvary cancerPersonalized medicinePoint mutationReal time polymerase chain reactionReverse transcription polymerase chain reactionReviewROS1 geneSingle nucleotide polymorphismTherapy resistanceTreatment responseVariant allele frequencyGeneticsLiquid biopsyLung tumorMutationNon small cell lung cancer