Şentürk, AyşegülÖzsu, Savaş SedatDuru, SerapÇakır, EbruUlaşlı, Sevinç SarınçKayhan, ServetGüzel, AygülYakar, FatihBerk, Serdar2023-01-132023-01-132017Şentürk, A. vd. (2017). ''Prognostic importance of central thrombus in hemodynamically stable patients with pulmonary embolism''. Cardiology Journal, 24(5), 508-514.1897-5593https://doi.org/10.5603/CJ.a2017.00211898-018Xhttps://journals.viamedica.pl/cardiology_journal/article/view/48792http://hdl.handle.net/11452/30448Uludağ University, School of Medicine, Department of Pulmonary Medicine, Bursa, TurkeyBackground: The association between mortality and localization of central thrombus in hemodynamically stable patients with pulmonary embolism (PE) is unclear. Sufficient data are not available to help clinicians to select between low molecular weight heparin (LMWH), unfractionated heparin (UFH) and thrombolytics for the management of central thrombus. The present study aims to investigate whether central thrombus in the pulmonary artery affects 30-day mortality rate, and to compare the outcomes of different treatment approaches in patients with central thrombus. Methods: This multi-central, prospective, observational study included 874 hemodynamically stable patients with PE confirmed by multidetector computed tomography scan. The localization of the emboli was evaluated and categorized as central (saddle or at least one main pulmonary artery), lobar or distal. The primary study outcome was 30-day all-cause mortality. Results: Localization of the emboli was central in 319 (36.5%) patients, lobar in 264 (30.2%) and distal in 291 (33.2%) patients. Seventy-four (8.5%) patients died during the 30-day follow-up period. All-cause mortality rate was 11.9%, 6.8% and 6.2% in patients with central, lobar, and distal emboli, respectively (p < 0.001). Multivariate analysis did not show that hemodynamically stable central thrombus was an independent predictor of mortality. Additionally, mortality rate was not significantly different between UFH, LMWH and thrombolytic therapy groups. Conclusions: The present study showed that central thrombus was not an independent predictor of mortality in hemodynamically stable PE patients. LMWH and UFH were similarly effective in the treatment of this patient group.eninfo:eu-repo/semantics/openAccessCardiovascular system & cardiologyAnticoagulationCentral thrombusMortalityMultidetector computed tomographyPulmonary embolismRisk stratİfİcatİonEmergency-departmentMultidetector ctTherapyThrombolysİsMetaanalysİsCombİnatİonBİomarkersHeparİnBurdenAdultAgedAged, 80 and overAnticoagulantsArterial occlusive diseasesChi-square distributionComputed tomography angiographyFemaleFibrinolytic agentsHemodynamicsHeparin, low-molecular-weightHumansMaleMiddle agedMultidetector computed tomographyMultivariate analysisOdds ratioProportional hazards modelsPulmonary arteryPulmonary embolismRisk factorsThrombolytic therapyThrombosisTime factorsTreatment outcomeTurkeyYoung adultArticle0004141527000072-s2.0-8503282156350851424528248408Cardiac & cardiovascular systemsLung Embolism; Embolectomy; Blood Clot LysisHeparinAnticoagulant agentFibrinolytic agentLow molecular weight heparinAgedArticleCentral thrombusComputer assisted tomographyControlled studyDyspneaFaintnessFemaleFollow upHemodynamicsHemoptysisHumanLung embolismMajor clinical studyMaleMortalityObservational studyProspective studyPulmonary arteryThorax painThrombusAdultChi square distributionClinical trialComparative studyComputed tomographic angiographyDiagnostic imagingEpidemiologyFibrinolytic therapyHemodynamicsLung embolismMiddle agedMortalityMulticenter studyMultidetector computed tomographyMultivariate analysisOdds ratioPathophysiologyPeripheral occlusive artery diseaseProceduresProportional hazards modelRisk factorThrombosisTime factorTreatment outcomeVery elderlyYoung adult