2024-03-212024-03-212008Özyurt, G. vd. (2008). "Comparison of SPECT findings and neuropsychological sequelae in carbon monoxide and organophosphate poisoning". Clinical Toxicology, 46(3), 218-221.1556-3650https://www.tandfonline.com/doi/full/10.1080/15563650701378704https://hdl.handle.net/11452/40537Abnormal regional cerebral blood flow in patients with acute carbon monoxide (CO) and organophosphate (OP) poisoning was examined using (99m) Tc-hexamethylpropylene amine oxime (HMPAO) brain single photon emission computed tomography (SPECT) in fourteen patients. We evaluated the predictive significance of acute phase brain SPECT findings for long-term neuropsychological sequelae. Changes were found in the frontal, temporal, parietal lobes within the first week after both types of poisoning. The distribution of the hypoperfused cerebral areas as demonstrated by (99m) Tc-HMPAO imaging was similar in the two groups during the acute phase. Neuropsychological sequelae developed in five patients poisoned with OP and six with CO. Patients who had SPECT findings heterogeneously or in the temporal or frontal lobes displayed disorientation. Those with fronto-parietal and frontal lobe changes displayed mental confusion. Parkinsonism also was observed in patients with parieto-occipital, parietal and frontal lobe lesions. The distribution of these lesions appears to predict the long term sequelae of these poisonings, though additional studies with larger numbers of patients are needed to confirm the role of SPECT imaging in both OP and CO poisonings.eninfo:eu-repo/semantics/closedAccessCarbon monoxide poisoningNeuropsychological sequelaeOrganophosphate poisoningSPECTEmission computed-tomographyHmpao brain spectNitric-oxideIntoxicationEncephalopathyNeuropathologyFeaturesMriToxicologyAdultBrainCarbon monoxide poisoningCarboxyhemoglobinFemaleHumansMaleNeuropsychological testsPhosphorica acid estersPoisoningRadiopharmaceuticalsTechnetium tc 99m exametazimeTomography, emission-computed, single-photonArticle0002540430000072-s2.0-4084909431321822146318344103https://doi.org/10.1080/15563650701378704ToxicologyCarbon Monoxide Intoxication; Acute; Hyperbaric Oxygen TherapyCarbon monoxideHexamethylpropylene amine oxime technetium tc 99mOrganophosphateArticleBrain blood flowBrain perfusionCarbon monoxide intoxicationClinical articleControlled studyDisorientationFemaleFrontal cortexFrontal lobeHumanMaleMental diseaseNeurotoxicityOccipital cortexParietal lobeParkinsonismSingle photon emission computer tomography