2022-09-122022-09-122007Özkan, T. B. vd. (2007). "Effect of Saccharomyces boulardii in children with acute gastroenteritis and its relationship to the immune response". Journal of International Medical Research, 35(2), 201-212.03000605https://doi.org/10.1177/147323000703500204https://journals.sagepub.com/doi/10.1177/147323000703500204http://hdl.handle.net/11452/28631We evaluated the effect of Saccharomyces boulardii administration in otherwise healthy children aged between 6 months and 10 years who were admitted for acute diarrhoea (15 males, 12 females). The patients were randomized into two groups: group 1 (n = 16) received 250 mg S. boulardii dissolved in 5 ml of water orally twice daily for 7 days and group 2 (n = 11) received placebo. Clinical and laboratory assessments were performed on admission and on day 7 of follow-up. Both groups experienced reduced daily stool frequency, the decrease being significantly greater in group 1 on days 3 and 4 compared with group 2. Group I demonstrated significant increases in serum immunoglobulin A and decreases in C-reactive protein levels on day 7. The percentage of CD8 lymphocytes on day 7 was significantly higher in group I than group 2. This study confirmed the efficacy of S. boulardii in paediatric acute gastroenteritis and the findings suggest that S. boulardii treatment enhances the immune response.eninfo:eu-repo/semantics/openAccessPaediatricsChildrenGastroenteritisBreast-feedingImmune responseProbioticsSaccharomyces boulardiiAntibiotic-associated diarrheaPlacebo-controlled trialLactobacillus ggt-cellsPreventionDiseaseProbioticsInfantsBetaArticle0002465903000042-s2.0-3424974366620121235217542407Medicine, research & experimentalPharmacology & pharmacySaccharomyces Cerevisiae Var. Cerevisiae; Clostridium Infections; Probiotic AgentReflorC reactive proteinImmunoglobulin APlaceboProbiotic agentUnclassified drugProtein blood levelControlled clinical trialAcute diarrheaAcute gastroenteritisArticleCD8+ T lymphocyteChildClinical trialControlled studyDouble blind procedureFemaleImmune responseFollow upHumanInfantOral rehydration therapyImmunoglobulin blood levelMaleLymphocyte countNonhumanRandomized controlled trialSaccharomyces boulardii