2022-07-072022-07-072010-05-28Duman, U. vd. (2010). "Anti-inflammatory efficiency of levobupivacaine in an experimental colitis model". World Journal of Gastroenterology, 16(20), 2537-2541.1007-93272219-2840https://doi.org/10.3748/wjg.v16.i20.2537https://www.wjgnet.com/1007-9327/full/v16/i20/2537.htmhttp://hdl.handle.net/11452/27792AIM: To investigate the efficiency of levobupivacaine in treating experimentally induced colitis in rats. METHODS: Colitis was induced by trinitrobenzene sulfonic acid and ethanol in 30 rats under general anesthesia, and 10 rats were used as a sham group. Subsequent to induction of colitis, rats were divided into three groups; budesonide group received 0.1 mg/kg budesonide, levobupivacaine group received 10 mg/kg levobupivacaine and saline group received 1 mL saline solution via rectal route for 7 d. In the sham group, only routine rectal catheterization was performed without use of any material. At the end of 7 d, laparotomy and total colectomy were performed for histopathological examination in all rats and blood samples were drawn for measurement of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 following cardiac puncture. Macroscopic and microscopic evaluations of the specimens were performed by a pathologist blinded to group assignment of the rats. RESULTS: Weight loss (P = 0.016) and macroscopic examination scores (P = 0.001) were significantly higher in saline group than others. Histopathological scoring was comparable between all colitis groups (P = 0.350). There was no significant difference in TNF-alpha levels and IL-6 levels (P = 0.150). CONCLUSION: The significant improvement in macroscopic scores suggests that levobupivacaine may have topical anti-inflammatory effects in an experimental colitis model; however, this finding was not supported by microscopic findings.eninfo:eu-repo/semantics/openAccessTrinitrobenzene sulfonic acidColitisLevobupivacaineBudesonideInflammatory-bowel-diseaseUlcerative-colitisLocal-anestheticsLidocaineRopivacaineProctitisTherapyCellsGastroenterology & hepatologyArticle0002781968000122-s2.0-7795326070425372541162020503454Gastroenterology & hepatologyLidocaine; Postoperative Nausea and Vomiting; IntravenousAlcoholBudesonideInterleukin 6LevobupivacaineSodium chlorideTrinitrobenzenesulfonic acidTumor necrosis factor alphaAnimal cellAnimal experimentAnimal modelAnimal tissueAntiinflammatory activityArticleBlood samplingCatheterizationColitisColon resectionControlled studyDrug efficacyEnteritisHistopathologyLaparotomyMaleNonhumanRatSingle drug doseWeight reduction