2021-09-072021-09-072006Osma, S. vd. (2006). ''Efficacy of antiseptic-impregnated catheters on catheter colonization and catheter-related bloodstream infections in patients in an intensive care unit''. Journal of Hospital Infection, 62(2), 156-162.0195-67011532-2939https://www.sciencedirect.com/science/article/pii/S0195670105002987https://doi.org/10.1016/j.jhin.2005.06.030http://hdl.handle.net/11452/21714This study was conducted to evaluate the impact of central venous catheters impregnated with chlorhexidine and silver sulphadiazine on the incidence of colonization and catheter-related bloodstream infection in critically ill patients. One hundred and thirty-three patients requiring central venous catheterization were chosen at random to receive either an antiseptic-impregnated triple-lumen catheter (N = 64) or a standard triple-lumen catheter (N = 69). The mean (SD) durations of catheterization for the antiseptic and standard catheters were 11.7 (5.8) days (median 10; range 3-29) and 8.9 (4.6) days (median 8.0; range 3-20), respectively (P = 0.006). Fourteen (21.9%) of the antiseptic catheters and 14 (20.3%) of the standard catheters had been colonized at the time of removal. (P = 0.834). Four cases (6.3%) of catheter-related bloodstream infection were associated with antiseptic catheters and one case (1.4%) was associated with a standard catheter (P = 0.195). The catheter colonization rates were 18.7/1000 catheter-days for the antiseptic catheter group and 22.6/1000 catheter-days for the standard catheter group (P = 0.640). The catheter-related bloodstream infection rates were 5.3/1000 catheter-days for the antiseptic catheter group and 1.6/1000 catheter-days for the standard catheter group (P = 0.452). In conclusion, our results indicate that the use of antiseptic-impregnated central venous catheters has no effect on the incidence of either catheter colonization or catheter-related bloodstream infection in critically ill patients.eninfo:eu-repo/semantics/closedAccessPublic, environmental & occupational healthInfectious diseasesCatheter-related bloodstream infectionCatheter colonizationAntiseptic-impregnated cathetersCentral venous cathetersCulturesPathogenesisChlorhexidineSepsisPreventionControlled trialBacterial-colonizationSilver-sulfadiazineCentral venous cathetersArticle0002352642000052-s2.0-3034447456515616262216307824Public, environmental & occupational healthInfectious diseasesCentral Venous Catheters; Catheter Infection; Vascular Access Devices