Tvarijonaviciute, AstaTecles, FernandoCeron, Jose J.2022-03-232022-03-232012-10Tvarijonaviciute, A. vd. (2012). "Serum butyrylcholinesterase and paraoxonase 1 in a canine model of endotoxemia: Effects of choline administration". Research in Veterinary Science, 93(2), 668-674.0034-52881532-2661https://doi.org/10.1016/j.rvsc.2011.09.010https://www.sciencedirect.com/science/article/pii/S0034528811003699http://hdl.handle.net/11452/25310Butyrylcholinesterase (BChE) and paraoxonase 1 (PON1) are two serum enzymes synthesized by the liver that are related with inflammation. The main objectives of this study were to determine changes in serum BChE and PON1 by using a canine model of endotoxemia, and to evaluate whether choline alters BChE and PON1 activities during inflammation. For this purpose, a total of 20 mongrel dogs were divided into four groups: control, choline (C), lipopolysaccharide (LPS), and LPS + C. Dogs in the control group were injected with 0.9% NaCl (0.2 ml/kg, i.v.). Dogs in C and LPS + C groups received choline chloride (20 mg/kg, i.v., three times with 4 h intervals). Endotoxin was injected (0.02 mg/kg, i.v., once) to the dogs of LPS and LPS + C groups. Statistically significant decreases in BChE and PON1 activities in LPS group were detected 24 and 48 h post injection, respectively. No statistically significant changes in BChE and PON1 activities at different times were detected in control, C, or LPS + C groups. In conclusion, the data obtained in present study revealed a decrease in serum BChE and PON1 activities in dogs during experimentally induced endotoxemia and that choline administration attenuates these changes.eninfo:eu-repo/semantics/closedAccessVeterinary sciencesBChECholineDogLipopolysaccharidePon1S1rsCdp-cholineWhole-bloodInvolvementMetabolitesInsulinSepsisInhibitionReceptorsDecreaseRatsAnimalsAryldialkylphosphataseBody temperatureButyrylcholinesteraseCholineDog diseasesDogsEndotoxemiaFemaleGene expression regulation, enzymologicLipopolysaccharidesMaleRespirationArticle0003068649000202-s2.0-8486387948366867493222000805Veterinary sciencesCiticoline; Neuroprotective Agents; GlycerylphosphorylcholineAryldialkylphosphatase 1CholineCholinesteraseEndotoxinLipopolysaccharideAcute phase responseAnimal experimentAnimal modelArticleControlled studyDogEndotoxemiaEnzyme activityEnzyme blood levelEnzyme synthesisFemaleMaleNonhuman